CIRCANNUAL RHYTHMS, BEHAVIOR AND REPRODUCTION

周期性节律、行为和繁殖

• 批准号: 3312705
• 负责人: IRVING ZUCKER
• 金额: $ 21.83万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3312705
• 关键词: adipocytes; adipose tissue; animal ecology; behavioral medicine; bioenergetics; biological clocks; biological information processing; bioperiodicity; biopsy; body composition; body weight; brain septal area; circadian rhythms; controlled environment chamber; experimental brain lesion; hibernation; hormone regulation /control mechanism; hypothalamus; juvenile animal; male castration; male reproductive system; mature animal; neuroendocrine system; photobiology; preoptic areas; psychophysiology; reproductive development; seasonal affective disorder; sex cycle; suprachiasmatic nucleus; temperature; testosterone; visual pathways; weight control

The main goals of the proposed research are to characterize the neuroendocrine substrates involved in generation of circannual rhythms in behavior and physiology, and to identify environmental stimuli that synchronize these endogenous rhythms. The model species to be studied is the golden-mantled ground squirrel. Specific projects include: 1) A definitive test of the role of day length in entrainment of circannual rhythms, 2) establishing the role of the retinohyothalamic tract in photic entrainment of circannual rhythms, 3) determining if the lateral septal nuclei, medial pre-optic region and mammillary nuclei are part of the neural substrate for generation and expression of circannual rhythms, 4) establishing whether the period of circadian rhythms is temperature-dependent during part of the circannual cycle, 5) evaluating interactions among body fat, energetics and reproduction during the circannual cycle, and, 6) establishing the sequence of lipid mobilization from different fat depots during the weight loss phase of the circannual cycle, as well as differences between juveniles and adults in number and size of adipocytes. Parameters to be measured include body mass, adipocyte number and size, plasma testosterone levels, circadian activity rhythms, and external reproductive condition. The proposed work is relevant to mechanisms that underlie endogenous seasonal affective disorders in human beings, and could ultimately lead to pharmacological as well as non-invasive treatments for these conditions.

拟议研究的主要目标是表征 神经内分泌底物参与每年产生 行为和生理的节律，并识别环境 同步这些内源节律的刺激。 型号 要研究的物种是金披地松鼠。 具体项目包括： 1）对白天角色的明确测试 昼夜节律夹带的长度，2）建立 视网膜下丘脑束在光夹带中的作用 昼夜节律，3) 确定外侧间隔核， 内侧视前区和乳头核是 产生和表达周期性神经元的神经基质 节律，4）确定昼夜节律的周期 在一年循环的一部分期间与温度相关，5) 评估身体脂肪、能量和能量之间的相互作用 每年循环期间的繁殖，以及，6) 建立 不同脂肪库的脂质调动顺序 一年一度的减肥阶段，以及 青少年和成人之间在数量和大小上的差异 脂肪细胞。 要测量的参数包括体重、 脂肪细胞数量和大小、血浆睾酮水平、昼夜节律 活动节律和外部生殖状况。 这 拟议的工作与内生机制相关 人类的季节性情感障碍，最终可能 导致药物和非侵入性治疗 这些条件。