CIRCANNUAL RHYTHMS, BEHAVIOR AND REPRODUCTION

周期性节律、行为和繁殖

• 批准号: 3312702
• 负责人: IRVING ZUCKER
• 金额: $ 18.8万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3312702
• 关键词: adipose tissue; adrenalectomy; biological clocks; biological information processing; body temperature regulation; body weight; circadian rhythms; corticosteroids; eating; estradiol; experimental brain lesion; gender difference; hibernation; hormone regulation /control mechanism; hypothalamus; juvenile animal; luteinizing hormone; mature animal; neuroendocrine system; psychobiology; sex cycle

The proposed work seeks to identify neural and endocrine mechanisms underlying the generation and entrainment of circannual rhythms of reproduction, body weight, food intake and hibernation. The species to be studied are the golden-mantled ground squirrel and the European hamster. Specific projects include: (1) Elaboration of the relation between circadian and circannual rhythms, in particular the role of frequency demultiplication of circadian rhythms as a mechanism for measuring circannual intervals (2) Assessment of the role of postnatal sexual differentiation for the development of seasonal sex differences in body weight and plasma luteinizing hormone levels (3) Determining the phase-shifting effects of estradiol on the circannual body weight cycle and specifying the sites within the hypothalamus at which estradiol influences circannual time-keeping processes (4) Establishing the role of lipids as synchronizers of circannual cycles in reproduction, hibernation and body weight. The effects of lipids on feedback regulation of food intake will be assessed at several phases of the circannual body weight cycle (5) comparison of the role of the suprachiasmatic nuclei as oscillators for circannual rhythms entrained by photoperiod versus those synchronized by non-photo-periodic zeitgebers (6) Evaluation of the role of adrenal steroids in the generation of circannual rhythms of plasma luteinizing hormone (7) Determination of hormone secretory patterns during homothermic and heterothermic phases of hibernation (8) Assessment of the role of the paraventricular nuclei in the generation of circannual rhythms. Parameters to be measured include body weight, food intake, locomotor activity, luteinzing hormone and testesterone levels in plasma, body temperature and several morphological and physiological indices of reproductive status. The proposed research will develop concepts and data relevant to understanding and manipulating human circannual rhythms presumed to underlie seasonal cycles in affective disorders.

拟议的工作旨在确定神经和内分泌机制 昼夜节律的产生和夹带的基础 繁殖、体重、食物摄入和冬眠。 所要的物种 研究对象是金毛地松鼠和欧洲仓鼠。 具体项目包括： (1) 阐述两者之间的关系 昼夜节律和年节律，特别是频率的作用 昼夜节律的消除作为测量机制 一年一次的间隔 (2) 评估产后性行为的作用 身体季节性性别差异发展的分化 体重和血浆黄体生成素水平 (3) 测定 雌二醇对体重周期的相移效应和 明确雌二醇影响下丘脑内的部位 每年的计时过程 (4) 确立脂质作为 生殖、冬眠和身体的周期性同步器 重量。 脂质对食物摄入反馈调节的影响 在一年一度的体重周期的几个阶段进行评估 (5) 视交叉上核作为振荡器的作用的比较 光周期带来的昼夜节律与光周期同步的昼夜节律 非光周期时间 (6) 肾上腺作用评价 类固醇在血浆黄体化的昼夜节律的产生中 激素 (7) 恒温期间激素分泌模式的测定 冬眠期和异温期 (8) 评估 室旁核参与昼夜节律的产生。 参数 测量的内容包括体重、食物摄入量、运动活动、 血浆中的黄体生成素和睾酮水平、体温和 生殖状态的几种形态和生理指标。 拟议的研究将开发相关概念和数据 理解和操纵人类的昼夜节律 是情感障碍季节性周期的基础。