SYNTHESIS OF NOVEL MARINE HETEROCYCLES

新型海洋杂环化合物的合成

• 批准号: 3303965
• 负责人: MICHAEL P CAVA
• 金额: $ 15.98万
• 依托单位: UNIVERSITY OF ALABAMA IN TUSCALOOSA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3303965
• 关键词: Porifera; Tunicata; X ray crystallography; alkaloids; antineoplastics; antiviral agents; chemical structure; chemical structure function; chemical synthesis; cytotoxicity; drug adverse effect; heterocyclic compounds; indoles; marine biology; tissue /cell culture

In recent years, a number of biologically active compounds having unusual heterocyclic structures have been isolated from a variety of marine organisms, especially sponges and tunicates. The goal of this proposal is the total synthesis of four of these compounds, all of which are novel marine indole alkaloids. They include the cytotoxic sponge alkaloids discorhabdin C, prianosin A, manzamine C and dragmacidin. All of the above represent structural types which have not yet been synthesized.

近年来，许多具有不寻常的生物活性化合物 杂环结构已从各种海洋中分离出来 生物，尤其是海绵和双束。 该提议的目的是 这些化合物中的四种的总合成，所有这些都是新颖的 海洋吲哚生物碱。 它们包括细胞毒性海绵生物碱 Discorhabdin C，Prianosin A，Manzamine C和Dragmacidin。 上述所有的 表示尚未合成的结构类型。