SYNTHESIS OF TROPLOISOQUINOLINE ALKALOIDS

原异喹啉生物碱的合成

• 批准号: 3298926
• 负责人: MICHAEL P CAVA
• 金额: $ 7.13万
• 依托单位: UNIVERSITY OF ALABAMA IN TUSCALOOSA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3298926
• 关键词: Brazil; alkaloids; cyclic compound; cyclic ketone; drug design /synthesis /production; isoquinolines; malonates; plant extracts

Imerubrine and grandirubrine are the only known examples of the novel group of tropoloisoquinoline alkaloids. These are the minor alkaloids from several species of Abuta, which are topical vines belonging to the family Menispermaceae. The pharmacological properties of these unusual and rare bases are unknown and neither alkaloid has been synthesized as yet. The goal of this proposal is to synthesize imerubrine and grandirubrine as well as the parent troponoisoquinoline system by using several unrelated synthetic strategies.

imerubrine和Grandirubrine是新小组的唯一已知例子 Tropoloisoquinoline生物碱。 这些是来自 属于家族的几种阿布塔（Abuta）的种类 Menispermaceae。 这些不寻常且罕见的药理特性 碱是未知的，尚未合成生物碱。 这 该提议的目标是合成imerubrine和Grandirubrine 作为母体troponoisoquinoline系统，通过使用几个无关的 合成策略。