BBSRC Institute Strategic Programme: Building Robustness in Crops (BRIC) Partner Grant

BBSRC 研究所战略计划：增强作物稳健性（金砖四国）合作伙伴赠款

• 批准号: BB/Y003039/1
• 负责人: Thomas Wood
• 金额: $ 4.37万
• 依托单位: National Institute of Agricultural Botany
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY003039%2F1
• 关键词: BBSRC; Institute; Strategic; Programme; Building

Climate change is challenging crop production and our ability to produce enough high-quality food to feed a growing population. Most modern crop varieties have not been bred to withstand and produce reliably under variable or extreme climatic conditions. As agricultural systems progress towards net-zero by 2050 we need to develop crops that are not only resilient to climate perturbations producing high yields on reduced area of land but that have the developmental robustness to withstand pests and disease whilst providing us with sustainable, healthy food, with reduced dependence upon agrochemical inputs. The aim of the Building Robustness in Crops ISP is to deliver genetic diversity and knowledge, innovative technologies and training to allow robust high-yielding crops to be developed with a better understanding of the agronomic practices required for sustainable production with minimum inputs. Our research programme has been developed through consultation with industry to identify key problems and challenges. We will use an interdisciplinary approach combining our research expertise in genetics/genomics with computational biology, modelling and imaging and we will engage with social scientists and climate scientists through the Norwich Institute for Sustainable Development to enhance the breadth of our expertise. These approaches will enable us to deliver models for crop breeding that predict the effects of genes on morphology and enable a targeted approach to crop modification for traits such as fertility, vigour, chilling tolerance, winter hardiness, pollinator attraction, drought tolerance and herbivore resistance. We will work with the plant breeding industry, growers, policy makers and broader stakeholder groups to ensure that the knowledge we produce will drive development and improvements across the sector.We will build resources and technologies for both UK and global crop improvement. We will develop and grow genetic diversity panels in oilseed rape and pea to identify beneficial traits which can be incorporated in future crop varieties. The field-grown resources that we deliver with our collaborators and partners will be a community resource that can be used by other research institutions and industry. This will allow exploitation of accompanying genetic resources for incorporation of novel breeding targets such as improved flowering time, yield, architecture, quality, and disease resistance enabling UK breeding programmes to develop robust new varieties.We will improve our world-leading genome editing capabilities in Brassica and pea crops enhancing transformation efficiencies and regeneration of tissue. Improved capability will allow us to engineer more complex pathways of genes within crop plants and allow faster progress to be made in developing crops that can then be tested in the field.Using Brassica and pea, as well as wheat and model species, we will investigate the mechanisms by which genes control and regulate plant traits and the influence environmental factors such as temperature have on these regulatory mechanisms. This will inform development of our genome editing protocols and the genetics needed for plants to withstand fluctuating environmental conditions.An Institute Strategic Programme provides an outstanding opportunity to align a large group of expert investigators, each with specialist skills but all working towards a common goal to tackle some of societies greatest challenges. We will build on previous BBSRC investment in both people and resources, using the state-of-the-art equipment and technology available to us. We will work with collaborators and partners at other BBSRC institutes, NIAB, universities and in industry, combining our expertise and pooling our resources to undertake exciting experimental designs that are only now becoming feasible.

气候变化正在挑战农作物生产以及我们生产足够的高质量粮食来养活不断增长的人口的能力。大多数现代作物品种尚未培育出能够在多变或极端气候条件下可靠生产的能力。随着农业系统到 2050 年实现净零排放，我们需要开发的作物不仅能够抵御气候扰动，在减少的土地面积上获得高产，而且具有发育稳健性，能够抵御病虫害，同时为我们提供可持续、健康的食物，减少对农用化学品投入的依赖。建立作物稳健性 ISP 的目标是提供遗传多样性和知识、创新技术和培训，以便在更好地了解以最少投入实现可持续生产所需的农艺实践的同时，开发出稳健的高产作物。我们的研究计划是通过与行业协商制定的，以确定关键问题和挑战。我们将采用跨学科方法，将遗传学/基因组学的研究专业知识与计算生物学、建模和成像相结合，并将通过诺维奇可持续发展研究所与社会科学家和气候科学家合作，以增强我们专业知识的广度。这些方法将使我们能够提供作物育种模型，预测基因对形态的影响，并能够针对肥力、活力、耐冷性、耐寒性、授粉媒介吸引力、耐旱性和抗草食性等性状对作物进行有针对性的改良。我们将与植物育种行业、种植者、政策制定者和更广泛的利益相关者群体合作，确保我们产生的知识将推动整个行业的发展和改进。我们将为英国和全球作物改良建立资源和技术。我们将开发和培育油菜和豌豆的遗传多样性小组，以确定可纳入未来作物品种的有益性状。我们与合作者和合作伙伴提供的实地资源将成为可供其他研究机构和行业使用的社区资源。这将允许利用伴随的遗传资源来纳入新的育种目标，例如改善开花时间、产量、结构、质量和抗病性，使英国育种计划能够开发出强大的新品种。我们将提高我们世界领先的基因组编辑能力芸苔属和豌豆作物提高转化效率和组织再生。改进的能力将使我们能够在作物植物内设计更复杂的基因途径，并在开发可在田间进行测试的作物方面取得更快的进展。我们将使用芸苔属和豌豆以及小麦和模型物种进行研究基因控制和调节植物性状的机制以及温度等环境因素对这些调节机制的影响。这将为我们的基因组编辑方案的开发以及植物承受波动的环境条件所需的遗传学提供信息。研究所战略计划提供了一个绝佳的机会来协调一大批专家研究人员，每个人都拥有专业技能，但都致力于一个共同的目标解决一些社会面临的最大挑战。我们将利用 BBSRC 之前在人力和资源方面的投资，利用我们现有的最先进的设备和技术。我们将与其他 BBSRC 研究所、NIAB、大学和工业界的合作者和合作伙伴合作，结合我们的专业知识并汇集我们的资源，进行令人兴奋的实验设计，这些设计现在才变得可行。