BBSRC Institute Strategic Programme: Building Robustness in Crops (BRIC) Partner Grant

BBSRC 研究所战略计划：增强作物稳健性（金砖四国）合作伙伴赠款

• 批准号: BB/Y003039/1
• 负责人: Thomas Wood
• 金额: $ 4.37万
• 依托单位: National Institute of Agricultural Botany
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY003039%2F1
• 关键词: BBSRC; Institute; Strategic; Programme; Building

Climate change is challenging crop production and our ability to produce enough high-quality food to feed a growing population. Most modern crop varieties have not been bred to withstand and produce reliably under variable or extreme climatic conditions. As agricultural systems progress towards net-zero by 2050 we need to develop crops that are not only resilient to climate perturbations producing high yields on reduced area of land but that have the developmental robustness to withstand pests and disease whilst providing us with sustainable, healthy food, with reduced dependence upon agrochemical inputs. The aim of the Building Robustness in Crops ISP is to deliver genetic diversity and knowledge, innovative technologies and training to allow robust high-yielding crops to be developed with a better understanding of the agronomic practices required for sustainable production with minimum inputs. Our research programme has been developed through consultation with industry to identify key problems and challenges. We will use an interdisciplinary approach combining our research expertise in genetics/genomics with computational biology, modelling and imaging and we will engage with social scientists and climate scientists through the Norwich Institute for Sustainable Development to enhance the breadth of our expertise. These approaches will enable us to deliver models for crop breeding that predict the effects of genes on morphology and enable a targeted approach to crop modification for traits such as fertility, vigour, chilling tolerance, winter hardiness, pollinator attraction, drought tolerance and herbivore resistance. We will work with the plant breeding industry, growers, policy makers and broader stakeholder groups to ensure that the knowledge we produce will drive development and improvements across the sector.We will build resources and technologies for both UK and global crop improvement. We will develop and grow genetic diversity panels in oilseed rape and pea to identify beneficial traits which can be incorporated in future crop varieties. The field-grown resources that we deliver with our collaborators and partners will be a community resource that can be used by other research institutions and industry. This will allow exploitation of accompanying genetic resources for incorporation of novel breeding targets such as improved flowering time, yield, architecture, quality, and disease resistance enabling UK breeding programmes to develop robust new varieties.We will improve our world-leading genome editing capabilities in Brassica and pea crops enhancing transformation efficiencies and regeneration of tissue. Improved capability will allow us to engineer more complex pathways of genes within crop plants and allow faster progress to be made in developing crops that can then be tested in the field.Using Brassica and pea, as well as wheat and model species, we will investigate the mechanisms by which genes control and regulate plant traits and the influence environmental factors such as temperature have on these regulatory mechanisms. This will inform development of our genome editing protocols and the genetics needed for plants to withstand fluctuating environmental conditions.An Institute Strategic Programme provides an outstanding opportunity to align a large group of expert investigators, each with specialist skills but all working towards a common goal to tackle some of societies greatest challenges. We will build on previous BBSRC investment in both people and resources, using the state-of-the-art equipment and technology available to us. We will work with collaborators and partners at other BBSRC institutes, NIAB, universities and in industry, combining our expertise and pooling our resources to undertake exciting experimental designs that are only now becoming feasible.

气候变化是挑战性的作物生产，我们有能力生产足够的高质量食物来养活不断增长的人群。在可变或极端气候条件下，大多数现代作物品种尚未繁殖以承受并可靠地产生。随着到2050年的农业系统向净零净发展，我们需要开发农作物，这些农作物不仅可以抵御气候扰动，从而在降低的土地面积上产生高收益率，而且具有发育的鲁棒性，可以承受害虫和疾病，同时使我们拥有可持续的，健康的食物，并降低了对农业化学输入的依赖。农作物ISP中建筑鲁棒性的目的是提供遗传多样性和知识，创新技术和培训，以便开发出强大的高产农作物，以更好地了解最低投入的可持续生产所需的农艺学实践。我们的研究计划是通过与行业咨询来制定的，以确定关键问题和挑战。我们将使用一种跨学科方法，将遗传学/基因组学方面的研究专业知识与计算生物学，建模和成像结合在一起，我们将通过诺里奇可持续发展研究所与社会科学家和气候科学家互动，以增强我们的专业知识的广度。这些方法将使我们能够提供农作物育种模型，以预测基因对形态的影响，并为诸如生育能力，活力，寒冷耐受性，冬季耐受性，授粉症状，干旱耐受性和草药抗性等性状的靶向作物修饰。我们将与植物育种行业，种植者，政策制定者和更广泛的利益相关者群体合作，以确保我们产生的知识将推动整个行业的发展和改进。我们将为英国和全球作物改善建立资源和技术。我们将在油料种子强奸和豌豆中发展和发展遗传多样性面板，以识别可以将其纳入未来作物品种中的有益特征。我们与合作者和合作伙伴一起提供的现场资源将是其他研究机构和行业可以使用的社区资源。这将允许对随附的遗传资源进行开发，以纳入新型繁殖目标，例如改善开花时间，产量，建筑，质量和抗病性，从而使英国育种计划能够开发出强大的新品种。我们将提高我们世界领先的基因组编辑能力，并在铜管和豌豆作物中增强转化的转化效率。提高的能力将使我们能够在作物植物中设计基因的更复杂的途径，并可以在开发的农作物中更快地进展，然后在田间进行测试。使用胸罩和豌豆，以及小麦和模型物种，我们将研究基因控制和调节植物特征以及对这些调节机制等温度的影响的机制。这将为我们的基因组编辑方案的开发以及植物所需的遗传学来承受可观的环境状况。我们将使用可用的最先进的设备和技术来基于对人和资源的先前对人和资源的投资。我们将与其他BBSRC研究所，NIAB，大学和行业的合作者和合作伙伴合作，结合我们的专业知识并汇集我们的资源，以进行令人兴奋的实验设计，而这些设计直到现在才变得可行。