PANACEA: Pathogenomics for enhancing food security in East Africa

PAACEA：加强东非粮食安全的病理基因组学

• 批准号: BB/R015376/1
• 负责人: Thomas Wood
• 金额: $ 14.9万
• 依托单位: National Institute of Agricultural Botany
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR015376%2F1
• 关键词: PANACEA; Pathogenomics; enhancing; food; security

SummaryCommon bean is an essential source of nutrients, vitamins and minerals to approximately 300 million consumers worldwide. Pest and disease, such as angular leaf spot (ALS) caused by Pseudocercospora griseola, can seriously reduce yields and quality, leading to malnutrition and lost incomes. Farmers often rely on growing resistant varieties to combat the effects of disease but unfortunately ALS is genetically diverse, so selecting the best-performing varieties can be problematic. Providing resources for pathotyping fungal pathogens like ALS can help researchers and plant breeders to improve disease management, variety selection and guide the development of new, resistant varieties to help growers to stabilise productivity and to reduce the incidence and severity of disease outbreaks. The pump-priming project will help to establish new, innovative biological and bioinformatics resources that will provide local experts and researchers with enhanced capability to accurately monitor for differences in ALS races. This will enable new or novel pathotypes to be identified when arise, and if they pose a potential threat to a growing region, allowing for interventions to be made in good time. The resources will comprise of:i) An initial pathogen collection of 75-100 P. griseola isolates sampled from across the nine different Ugandan agro-ecologiesii) Genomic resources developed around the panel providing genotyping information for pathotyping and functional studiesiii) A population diversity screen using the new genomic resource to begin to shed light on ALS pathotypes affecting East African bean cropsiv) Series of meetings, webinars and workshops to optimise the new resources for end-user utility and demonstrate the new resource to stakeholders and local experts.The new resources will begin to facilitate improved monitoring and surveillance of P. griseola the causal agent of ALS on common bean in order to help prevent future disease outbreaks and to guide variety selection and the breeding of new varieties. This will contribute directly to stabilise yields and productivity, enhancing nutritional intakes and incomes for small-holder farmers and the millions of consumers dependent on common bean as a cheap, nutritious source of food. The resources will also have wider application to scientific researchers with interests in more fundamental aspects of pathogen genomics and epidemiology. The initial framework developed during the project could be applied to other crops/pathogens to support further improvement efforts.

摘要 普通豆是全球约 3 亿消费者的营养、维生素和矿物质的重要来源。病虫害，例如灰假尾孢引起的角斑病（ALS），会严重降低产量和质量，导致营养不良和收入损失。农民通常依靠种植抗病品种来对抗疾病的影响，但不幸的是，ALS 具有遗传多样性，因此选择表现最好的品种可能会存在问题。为 ALS 等真菌病原体的致病分型提供资源可以帮助研究人员和植物育种者改善疾病管理、品种选择并指导新的抗性品种的开发，从而帮助种植者稳定生产力并降低疾病爆发的发生率和严重程度。泵启动项目将有助于建立新的、创新的生物和生物信息学资源，为当地专家和研究人员提供增强的能力，以准确监测 ALS 种族的差异。这将使新的或新颖的致病型在出现时能够被识别出来，并且如果它们对不断增长的地区构成潜在威胁，则可以及时采取干预措施。这些资源将包括：i) 从乌干达九个不同的农业生态系统中采样的 75-100 个 P. griseola 分离株的初始病原体收集ii) 围绕小组开发的基因组资源，为病理分型和功能研究提供基因分型信息iii) 群体多样性筛选使用新的基因组资源开始阐明影响东非豆类作物的 ALS 致病型iv) 系列会议、网络研讨会和研讨会，以优化最终用户效用的新资源并向利益相关者和当地专家展示新资源。新资源将开始促进改善对普通豆 ALS 病原体 P. griseola 的监测和监测，以帮助预防未来疾病爆发并指导品种选择和育种新品种。这将直接有助于稳定产量和生产力，提高小农和数以百万计依赖普通豆作为廉价、营养食品来源的消费者的营养摄入和收入。这些资源还将更广泛地应用于对病原体基因组学和流行病学更基本方面感兴趣的科学研究人员。该项目期间制定的初步框架可以应用于其他作物/病原体，以支持进一步的改进工作。