NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

NMR-BASE：在支持的环境中进行生物分子分析的核磁共振

• 批准号: BB/X019594/1
• 负责人: John Parkinson
• 金额: $ 145.02万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX019594%2F1
• 关键词: NMR; BASE; Nuclear; Magnetic; Resonance

The biggest challenge in the invention of new biomedicines and biomaterials is understanding how they function at a molecular level in the context for which they are designed to work. While it is possible and necessary to examine such materials in isolation, their true purpose is revealed in their real living contexts or mimics of these. To bridge the gap that exists at the level of how designed medicines work, the NMR-BASE facility will be established to help users "see" the behaviour of their molecules in complex matrices, those that are significant in the context of therapeutic purpose. NMR-BASE will be established for the UK scientific community by providing researchers with access to state-of-the-art equipment to examine the fine details of molecular structure and behaviour in ways which will help the molecule design process to progress. The equipment will be suitable for the widest range of sample types and will be capable of supporting live cells as well as providing access to the study of tissues, gels and other "soft" materials that form the basis of many biological materials and systems. The equipment will enable a variety of scientific approaches to be used for studying molecules in their true contexts and will benefit the design process for new medicines and biomaterials. It will provide new training opportunities for a wide UK user base including PhD students both locally and nationally, providing access to unique equipment for their research along with the staff to support them. The equipment will be housed within the NMR Facility at the University of Strathclyde, a world-leading technological university which has the skills and expertise required to host and run NMR-BASE optimally.

新的生物医学和生物材料发明的最大挑战是了解它们在设计用于工作的背景下如何在分子层面上发挥作用。尽管有可能孤立地检查此类材料，但它们的真实目的是在其真实的生活环境或模仿中揭示的。为了弥合设计药物如何工作级别的差距，将建立NMR基本设施，以帮助用户“查看”其分子在复杂矩阵中的行为，这些矩阵在治疗目的的背景下很重要。 NMR基础将通过为研究人员提供最先进的设备来建立英国科学界的基础，以通过方式检查分子结构和行为的精细细节，这将有助于分子设计过程进行进步。该设备将适用于最广泛的样品类型范围，并且能够支持活细胞，并提供研究组织，凝胶和其他“软”材料的研究，这些材料构成了许多生物材料和系统的基础。该设备将使各种科学方法用于研究分子的真实情况，并将受益于新药物和生物材料的设计过程。它将为包括当地和全国范围内的博士生在内的广泛的英国用户群提供新的培训机会，从而为他们的研究提供独特的设备，并与员工一起为他们提供支持。该设备将安置在Strathclyde大学的NMR设施中，这是一所世界领先的技术大学，具有最佳托管和运营NMR基础所需的技能和专业知识。