MODULATION OF COCHLEAR NUCLEUS CHANGE IN THE DEAF

聋人耳蜗核变化的调节

• 批准号: 3080287
• 负责人: John K. Niparko
• 金额: $ 6.37万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3080287
• 关键词: auditory deprivation; auditory pathways; autoradiography; cochlea; cochlear implants; cochlear nerve; congenital deafness; deafness; disease /disorder model; dogs; electrostimulus; evoked potentials; guinea pigs; neural degeneration

Afferent input is critically important for normal development of central auditory nuclei. This project will assess the capacity of a cochlear prosthesis to provide such input in a congenitally deaf animal model. The proposed series of studies will compare morphometric and physiologic changes in the central auditory tract in deaf Dalmatians stimulated with a multichannel cochlear prosthesis with similar measures in untreated deaf and hearing Dalmatians of similar age. These studies will extend current work on changes in the peripheral auditory tract of the deaf Dalmatian. The rationale for these studies is based on 1) observations that auditory deprivation induces measurable changes in the volume of defined cell regions of central auditory nuclei and cell size, 2) auditory tract pathologic changes exhibited by the deaf Dalmatian that suggest it to be an especially appropriate model of congenital human deafness, and 3) early studies that suggest that electrical stimulation may exert a trophic effect on neurons of the peripheral auditory tract. It is anticipated that results from these studies will provide fundamental neuroanatomic information crucial to understanding the effects of prosthetic intervention in early human deafness. These studies are the focus of this 5 year Clinician Investigator Development Award application. Extended g in morphometric, electrophysiologic and statistical analysis will be organized around the proposed project. This training will be used to provide a basic framework that will complement a comprehensive neurotologic program of study of early sensorineural hearing loss and its treatment.

传入输入对于中枢神经系统的正常发育至关重要 听觉核团。 该项目将评估人工耳蜗的能力 假体在先天性耳聋动物模型中提供此类输入。这 拟议的一系列研究将比较形态测量和生理学 聋达尔马提亚犬中枢听觉系统的变化 多通道人工耳蜗对未经治疗的聋人采取类似措施 和年龄相仿的听力斑点狗。这些研究将扩展当前 研究聋哑达尔马提亚狗周围听觉系统变化的研究。这 这些研究的基本原理基于 1) 听觉观察 剥夺会导致特定细胞体积发生可测量的变化 中枢听觉核区域和细胞大小，2) 听觉道 聋达尔马提亚犬表现出的病理变化表明它是一种 特别适合先天性人类耳聋的模型，以及 3) 早期 研究表明电刺激可能发挥营养​​作用 对周围听觉道神经元的影响。预计结果 这些研究将提供基本的神经解剖学信息 对于理解早期假肢干预的影响至关重要 人类的耳聋。 这些研究是本 5 年临床研究者的重点 发展奖申请。形态测量中的扩展 g， 电生理学和统计分析将围绕 拟议的项目。该培训将用于提供基本框架 这将补充早期的综合神经学研究计划 感音神经性听力损失及其治疗。