Central Auditory system Effects of Auditory Deprivation

中枢听觉系统 听觉剥夺的影响

• 批准号: 6870231
• 负责人: Debara L. Tucci
• 金额: $ 31.79万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6870231
• 关键词: acoustic nerve; auditory cortex; auditory deprivation; auditory pathways; auditory threshold; autoradiography; chronic disease /disorder; conductive hearing loss; disease /disorder model; disease /disorder onset; early experience; electrical measurement; electrophysiology; gerbil /jird; immunocytochemistry; in situ hybridization; laboratory mouse; language development; neural information processing; neuroanatomy; otitis media; sound frequency; speech; verbal learning

DESCRIPTION (provided by applicant):The long-term goal of this work is to understand the structural and functional changes imposed on the central auditory system by conductive hearing impairment. A secondary goal is to determine the factors that govern the potential for reversibility of these changes. The clinical implications of this work are that many children experience conductive hearing loss during early development, in a time period that coincides with that of rapid acquisition of speech and language skills. Childhood conductive hearing loss is known to be associated with deficits in auditory processing skills, some of which persist even after the return of normal hearing. The nature of the functional and neuroanatomical changes in the central auditory system that underlie these deficits is unknown. The hypothesis underlying this proposal is that chronic conductive hearing impairment in early life results in structural changes in the central auditory systems, which are related to functional deficits in central auditory processing. These effects are age-dependent, and more severe in the developing animal. The severity of the structural change will affect the potential for reversibility when normal hearing is reinstated. Experiments are proposed to achieve three specific aims designed to address this hypothesis: 1) to define the effects of conductive hearing loss on activity in the auditory nerve and central auditory system, and assess the agedependent interactions; 2) to define the metabolic and structural changes that occur following unilateral conductive hearing loss in the developing and mature animal; and 3) to investigate factors that govern the reversibility of the above changes. We hypothesize that the potential for reversibility will depend upon the type and severity of the structural modification induced by conductive impairment, and the developmental stage of the animal at the time of the insult.

描述（由申请人提供）：这项工作的长期目标是 了解中央的结构和功能变化 听觉系统受到传导性听力障碍。第二个目标是 确定控制这些可逆性潜力的因素 变化。这项工作的临床意义是许多儿童 在早期发育过程中的一段时间内经历传导性听力损失 这与快速获得言语和语言技能的过程是一致的。 众所周知，儿童传导性听力损失与听力缺陷有关。 听觉处理技能，其中一些甚至在回归后仍然存在 正常听力。功能和神经解剖学变化的本质 导致这些缺陷的中枢听觉系统尚不清楚。 该提议的假设是慢性传导性听力 生命早期的损伤导致中枢听觉结构的变化 系统，与中枢听觉功能缺陷有关 加工。这些影响与年龄有关，并且在发展中国家更为严重 动物。结构变化的严重程度将影响潜在的 当恢复正常听力时，可逆性。建议进行实验 实现旨在解决这一假设的三个具体目标：1）定义 传导性听力损失对听神经活动的影响 中枢听觉系统，并评估年龄相关的相互作用； 2）定义 单侧传导后发生的代谢和结构变化 发育中和成熟动物的听力损失； 3）调查因素 控制上述变化的可逆性。我们假设 可逆性的可能性取决于该现象的类型和严重程度 传导障碍引起的结构改变和发育 动物受到侮辱时所处的阶段。