Revealing the circuit mechanisms of altered conscious perception with neuropixels recordings and biophysically-inspired neural networks.

通过神经像素记录和生物物理学启发的神经网络揭示改变意识感知的回路机制。

• 批准号: BB/X013243/1
• 负责人: Sean Froudist-Walsh
• 金额: $ 25.39万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX013243%2F1
• 关键词: Revealing; circuit; mechanisms; altered; conscious

Psilocybin is a compound found in 'magic mushrooms' that alters conscious perception. Our goal is to understand how psilocybin changes brain connectivity and conscious perception. To achieve this, we will bring together experts in brain anatomy and function with experts in artificial intelligence. We will first analyse and combine data on the brain's anatomy and function. We will use this data to simulate the effects of psilocybin on the brain's circuits. We can then analyse the simulation to learn how psilocybin changes brain activity and the conscious experience.Psilocybin has exploded in popularity as a recreational drug, a mental health treatment and an aid for creativity. The popularity derives in part from its effects on conscious perception. Conscious perception emerges from activity across scales of brain organisation. We aim to integrate across these scales. In this way, we will learn how the local effects of psilocybin lead to reorganisation of connections across the brain.The nature of the psilocybin experience does not only depend on biological factors. The mental state of the person taking the drug also affects the experience. We need to know how mental states can change psilocybin's effects on neural circuits. This would show how psychological and biological factors influence each other and determine our experience. Both natural chemical transmitters and drugs bind with receptors to open channels in neurons, much as a key fits a lock to open a door. We recently found the receptors that psilocybin binds to in different amounts across different brain areas. We aim to test whether this can explain the powerful influence of psilocybin on conscious perception. We propose to use a new advanced recording technology to measure psilocybin's effects on the activity of hundreds of neurons in the rat brain. We will combine this data with our maps of the locations of receptors in the brain. We will use this data to build a simulation of psilocybin's effects on the brain based on real biology. This will provide a missing link between the psychological and biological effects of psilocybin. Scientists can use this to design and refine future experiments.We have three key objectives:1. To analyse recordings of neural activity from the rat brain to identify how psilocybin's changes brain architecture.2. To simulate how the mental state can combine with biological factors and alter the psilocybin experience3. To simulate how the brain's physiology and anatomy determine psilocybin's ability to alter conscious perception. This project will create an open software platform to advance our understanding of psychedelic drugs. This has the potential to move forward both our fundamental understanding of the brain and drug development.

psilocybin是在“魔术蘑菇”中发现的一种化合物，可以改变有意识的感知。我们的目标是了解psilocybin如何改变大脑的连通性和有意识的感知。为了实现这一目标，我们将与人工智能专家汇集大脑解剖学专家和功能。我们将首先分析和结合有关大脑解剖结构和功能的数据。我们将使用这些数据来模拟psilocybin对大脑电路的影响。然后，我们可以分析模拟，以了解psilocybin如何改变大脑活动和有意识的体验。Psilocybin作为一种休闲药，一种心理健康治疗和创造力的援助在受欢迎程度上爆炸。受欢迎程度部分源于其对有意识感知的影响。有意识的感知来自跨大脑组织范围的活动。我们的目标是整合这些量表。通过这种方式，我们将学习psilocybin的局部影响如何导致整个大脑之间的联系重组。psilocybin体验的性质不仅取决于生物学因素。服用药物的人的精神状态也会影响体验。我们需要知道心理状态如何改变psilocybin对神经回路的影响。这将表明心理和生物学因素如何相互影响并确定我们的经验。天然化学发射器和药物都与受体结合，以打开神经元的通道，就像钥匙适合锁定的锁一起打开门。我们最近发现，psilocybin在不同大脑区域的不同量中结合的受体。我们旨在测试这是否可以解释psilocybin对有意识的感知的强大影响。我们建议使用一种新的先进记录技术来衡量psilocybin对大鼠大脑数百个神经元活动的影响。我们将将这些数据与大脑中受体位置的地图相结合。我们将使用这些数据来基于实际生物学对psilocybin对大脑的影响进行模拟。这将在psilocybin的心理和生物学作用之间提供缺失的联系。科学家可以使用它来设计和完善未来的实验。我们有三个关键目标：1。为了分析大鼠大脑的神经活动的记录，以确定psilocybin如何改变大脑结构。2。为了模拟精神状态如何与生物学因素结合并改变psilocybin体验3。为了模拟大脑的生理和解剖学如何确定psilocybin改变有意识的感知的能力。该项目将创建一个开放的软件平台，以提高我们对迷幻药物的了解。这有可能促进我们对大脑和药物发育的基本理解。

项目成果

Gradients of neurotransmitter receptor expression in the macaque cortex.

• DOI: 10.1038/s41593-023-01351-2
• 发表时间: 2023-07
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Froudist-Walsh, Sean;Xu, Ting;Niu, Meiqi;Rapan, Lucija;Zhao, Ling;Margulies, Daniel S. S.;Zilles, Karl;Wang, Xiao-Jing;Palomero-Gallagher, Nicola
• 通讯作者: Palomero-Gallagher, Nicola

Cell type-specific connectome predicts distributed working memory activity in the mouse brain.

• DOI: 10.7554/elife.85442
• 发表时间: 2024-01-04
• 期刊: eLife
• 影响因子: 7.7
• 作者: Ding X;Froudist-Walsh S;Jaramillo J;Jiang J;Wang XJ
• 通讯作者: Wang XJ