THE FUNCTION AND SYSTEMATIC ROLE OF NATURAL PRODUCTS

天然产品的功能和系统作用

• 批准号: 3288770
• 负责人: TOM J MABRY
• 金额: $ 7.73万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-10 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3288770
• 关键词: Compositae; Insecta; alkaloids; antibiotics; antineoplastic antibiotics; antineoplastics; chemical structure; drug screening /evaluation; evolution; flavonoids; genetic markers; molecular biology; nuclear magnetic resonance spectroscopy; nucleic acids; phenols; pheromone; physical chemical interaction; pigments; plant extracts; plant genetics; plant physiology; quinones; sesquiterpenes; systematic biology; terpenes

The project concerns assembling chemical and ultrastructural data in order to establish the way natural products function in plants as well as their role in coevolutionary systems involving plants and animals. The investigation emphasizes the phenolics, terpenoids and alkaloids present in members of the Compositae genera Helianthus and Artemesia, as well as other genera including especially Passiflora and Salvia. The antiherbivore, antimicrobial, allergenic contact dermatitis and antitumor activity of the isolated compounds are studied. The patterns of compounds encountered are used as genetic markers to understand phylogenetic relationships. New sequiterpene lactones, diterpene acids and flavonoid aglycones and their O- and C-glycosides have been isolated and structurally characterized by UV, NMR and MS spectral data as well as chemical derivatization and transformation.

该项目涉及组装化学和超微结构数据，以便 建立天然产品在植物中的运作方式以及它们在 涉及动植物的协同进化系统。 调查 强调酚类，萜类化合物和生物碱成员中存在的生物碱 复合属属Helianthus和Artemesia以及其他属包括 尤其是小虫和萨尔维亚。 抗小动物，抗菌，过敏性 研究了分离化合物的接触性皮炎和抗肿瘤活性。 遇到的化合物的模式被用作理解的遗传标记 系统发育关系。 新的丝氨酸内酯，二萜酸和 类黄酮类糖酮及其O-和C-糖苷已被隔离，并且 结构上以紫外线，NMR和MS光谱数据以及化学特征 衍生和转换。