OXIDATION CHEMISTRY OF INDOLES

吲哚的氧化化学

• 批准号: 3281126
• 负责人: GLENN DRYHURST
• 金额: $ 7.64万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-15 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3281126
• 关键词: 5 hydroxytryptophan; electrochemistry; indoles; neurotoxins; oxidation; quinones; serotonin; tryptophan

The specific aim of this project is to employ electrochemical and related analytical techniques to investigate the oxidation chemistry of a group of naturally occurring or otherwise biologically significant 3-substituted indoles. Among the compounds which will be investigated are tryptophan, 5-hydroxytryptamine, 5,6- and 5-7- dihydroxytryptamine, indole-3-acetic acid and various metabolities of these species. There is abundant literature evidence that these compounds undergo many oxidation reactions in living systems yet the mechanisms and products of these processes are not understood. In order to begin to understand the chemistry involved in such reactions a basic, fundamental study of the oxidation chemistry is required. It is believed that electrochemical and associated analytical methodologies provide the best techniques to study this oxidation chemistry. Our previous investigations have clearly shown that electrochemical studies of the oxidation and related chemistry of biological molecules can provide valuable insights into the biochemical oxidation mechanisms. It is expected that the planned studies on the oxidation chemistry of indoles will provide even more valuable information. It is planned to employ electrochemical and related techniques to define the redox potentials associated with the oxidation reactions of indoles, to chemically and physically characterize intermediates and to identify and quantitate products. Furthermore, it is hoped to develop an understanding of the interactions of putative oxidative intermediates such as quinones and quinoneimines with species commonly found in tissue. The ultimate goal of the proposed work is to provide a rational and systematic basis for understanding the oxidation chemistry of biologically significant indoles. This is turn should provide the basis for understanding the oxidation chemistry of indoles in living systems.

该项目的具体目的是采用电化学和相关 研究一组氧化化学的分析技术 天然发生或以其他方式发生生物学意义 吲哚。 在将要研究的化合物中有色氨酸， 5-羟色胺，5,6-和5-7-二羟色胺，吲哚-3-乙酰胺 这些物种的酸和各种代谢。 有很多 文献证据表明这些化合物经历了许多氧化反应 在生活系统中，这些过程的机制和产物是 不理解。 为了开始了解涉及的化学 这种反应是对氧化化学的基本基础研究是 必需的。 人们认为电化学和相关的分析 方法论提供了研究这种氧化的最佳技术 化学。 我们以前的调查清楚地表明 氧化和相关化学的电化学研究 生物分子可以为生化提供宝贵的见解 氧化机制。 预计计划的有关 吲哚的氧化化学将提供更有价值的 信息。 它计划采用电化学和相关 定义与氧化相关的氧化还原电位的技术 吲哚的反应，化学和物理表征 中间体并识别和定量产品。 此外，是 希望对推定氧化的相互作用有一种理解 中间体（例如奎因酮和奎诺明胺）与物种通常 在组织中发现。 拟议工作的最终目标是提供 理解理解的理性和系统基础 生物学意义的吲哚。 转弯应该提供基础 了解生命系统中吲哚的氧化化学。