GAS CHROMATOGRAPH-MASS SPECTROMETER-DATA SYSTEM

气相色谱-质谱仪-数据系统

• 批准号: 3519241
• 负责人: GLENN DRYHURST
• 金额: $ 22.5万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-02-01 至 1986-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519241
• 关键词: chemical synthesis; drug design /synthesis /production; electrochemistry; gas chromatography mass spectrometry; heterocyclic compounds; mass spectrometry; oxidation reduction reaction; chemical synthesis; drug design /synthesis /production; electrochemistry; gas chromatography mass spectrometry; heterocyclic compounds; mass spectrometry; oxidation reduction reaction

The Chemistry Department at the University of Oklahoma at present houses three programs which require substantial use of the analytical technique called GC/MS (coupled gas chromatography-mass spectrometry). These three programs cover research concerning the electrochemical and enzymatic oxidation of biologically important N-heterocyclic molecules, the synthesis of cancer-inducing agents, and the discovery and development of drugs for the treatment of cancer and cardiovascular disease. The importance of these programs cannot be overstated, and their success may be limited by the insufficient access to GC/MS capability which now exists. We propose to provide much improved capability through the acquisition and supported operation of a new GC/MS facility will not only provide a substantial increase in the accessibility of this technique to these programs, but also a substantial increase in the general capability of the instrumentation.

俄克拉荷马大学目前房屋的化学系 三个需要大量使用分析技术的程序 称为GC/MS（耦合气相色谱 - 质量光谱法）。 这三个 计划涵盖有关电化学和酶促的研究 生物学上重要的N-杂环分子的氧化，合成 癌症诱导剂，以及针对药物的发现和开发 治疗癌症和心血管疾病。 重要性 这些程序不能被夸大，它们的成功可能受到 现在存在的GC/MS功能的访问不足。 我们建议 通过收购提供大大提高的能力并支持 新的GC/MS设施的操作不仅可以提供实质性的 增加了此技术对这些程序的可访问性，但也会增加 仪器的一般能力大幅提高。