EXPERIMENTAL ENDOPHTHALMITIS

实验性眼内炎

• 批准号: 3261256
• 负责人: Denis M O'Day
• 金额: $ 13.7万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-03-01 至 1989-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3261256
• 关键词: Candida albicans; amphotericin B; antifungal agents; antifungal antibiotics; candidiasis; combination chemotherapy; corticosteroids; disease /disorder model; dosage; eye disorder chemotherapy; histopathology; human therapy evaluation; microorganism classification; postoperative complications; uveitis

The purpose of this grant proposal is to develop more effective treatment of post-surgical fungal endophthalmitis. A model of Candida sp. endophthalmitis will be developed in aphakic and pseudophakic pigmented outbred rabbits using quantitative mycological techniques for evaluation. In this model we will evaluate the efficacy of intravitreal amphotericin B therapy against infecting strains of varying susceptible to the agent. Dose response curves will be established. The value of systemic treatment with amphotericin B and ketoconazole, when given alone and in combination with intravitreal amphotericin B, will be assessed to determine the value, if any, of systemic treatment as compared to intravitreal therapy. THe influence of such factors as the presence of an intraocular lens and concomitantly administered corticosteroid on the infectious process will be investigated.

该赠款提案的目的是制定更有效的治疗 手术后真菌性内膜膜。 念珠菌的模型。 内嗜性将以蚜虫和伪造色素形式开发 使用定量的真菌学技术进行评估的杂种兔子。 在此模型中，我们将评估玻璃体内两性霉素B的功效 反对感染易感药物敏感的菌株的治疗。 将建立剂量反应曲线。 系统治疗的价值 与两性霉素B和酮康唑一起使用，单独给出并组合 使用玻璃体内两性霉素B，将评估以确定值 如果有的话，与玻璃体内治疗相比，全身治疗。 这 眼内晶状体和存在等因素的影响 在感染过程中同时给予皮质类固醇会 调查。