EXPERIMENTAL FUNGAL INFECTIONS OF THE EYE

眼部实验性真菌感染

• 批准号: 3256058
• 负责人: Denis M O'Day
• 金额: $ 22.36万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3256058
• 关键词: Aspergillus; Candida albicans; amphotericin B; antifungal agents; antifungal antibiotics; cooperative study; disease /disorder model; dosage; eye agent; eye disorder chemotherapy; eye infections; eye pharmacology; flucytosine; histopathology; human therapy evaluation; imidazole; keratitis; laboratory rabbit; microorganism culture; spores; virulence

Our purpose is to develop more effective ocular antifungal therapy by an enhanced understanding of the efficacy and pharmacokinetics of antifungal agents as they relate to the eye. Studies with susceptible and resistant strains of Candida albicans will be continued to determine whether within these groups there is true interstrain variation in response. A cooperative study between our laboratory and four other laboratories will investigate predictability and reproducibility of in vitro susceptibility testing and the correlation with in vivo response. The efficacy of imidazoles and flucytosine will be studied in an in vivo model and correlated with in vitro response. Models of Candida parapsilosis and Aspergillus fumigatus keratitis will be studied under similar conditions. Drug potentiation and interaction will be evaluated. Pharmacokinetic studies will be continued.

我们的目的是通过 对抗真菌的功效和药代动力学的了解增强 特工与眼睛有关。 具有易感性和抗性的研究 白色念珠菌菌株将继续确定是否内部 这些组有真正的应对变化。 一个 我们的实验室与其他四个实验室之间的合作研究将 研究体外易感性的可预测性和可重复性 测试和与体内反应的相关性。 的功效 将在体内模型中研究咪唑和氟胞菌素 与体外反应相关。 念珠菌的模型和 在类似条件下，将研究曲霉的角膜炎。 将评估药物增强和相互作用。 药代动力学 研究将继续。