Proposal for a Talos L120C G2 Transmission Electron Microscope

Talos L120C G2 透射电子显微镜提案

基本信息

批准号：
BB/S019707/1
负责人：
Vassilis Pachnis
金额：
$ 48.36万
依托单位：
The Francis Crick Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FS019707%2F1
关键词：
Proposal Talos L120C G2 Transmission

项目摘要

The Crick is a partnership between the Medical Research Council, Cancer Research UK, the Wellcome Trust and three leading universities: UCL (University College London), Imperial College London and King's College London. The Crick aspires to be one of the world's leading medical research institutes. The Crick achieves operational and research efficiencies and economies-of-scale through centralised facilities and functions, known as Science Operations, that provide all researchers at the Crick, irrespective of affiliation, with access to cutting-edge equipment, animals for research and laboratory enabling functions such as the Electron Microscopy Science Technology Platform (EM STP).Electron microscopy is a fundamental tool in bioscience research. It is used to image the structure of proteins, pathogens, cells and tissues, to help us understand the biological processes of normal development, disease states, and the effect of therapies.This proposal is for a new transmission electron microscope that will be used for state-of-the-art imaging experiments for 60-80 research projects ongoing at the Crick. The microscope has a range of additional features, including automated image stitching to allow us to view large samples and digitally zoom into features of interest (like 'google maps'); faster, more automated, three-dimensional imaging of samples using a technique called electron tomography; and a cryo-stage for imaging samples encased in ice, as close to their living state as possible.

Crick是医学研究委员会，英国癌症研究委员会，惠康基金会和三所主要大学之间的合作伙伴关系：UCL（伦敦大学学院），伦敦帝国学院和伦敦国王学院。克里克渴望成为世界领先的医学研究机构之一。克里克通过集中式设施和功能（称为科学运营）实现运营和研究效率以及规模经济，这些功能可为Crick的所有研究人员提供，无论隶属关系如何电子显微镜科学技术平台（EM STP）等功能。电子显微镜是生物科学研究中的基本工具。它用于成像蛋白质，病原体，细胞和组织的结构，以帮助我们了解正常发育，疾病状态和疗法的影响。该提案用于新的传输电子显微镜，该显微镜将用于Crick正在进行的60-80个研究项目的最新成像实验。显微镜具有一系列其他功能，包括自动图像缝线，使我们能够查看大型样本并将数字放大为感兴趣的功能（例如“ Google Maps”）；使用称为电子断层扫描的技术对样品进行更快，更自动化的三维成像；以及将冰包裹在冰中的成像样品的冷冻阶段，尽可能靠近它们的生活状态。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication.

DOI：
10.1099/jgv.0.001702
发表时间：
2021-12
期刊：
The Journal of general virology
影响因子：
0
作者：
Falci Finardi N;Kim H;Hernandez LZ;Russell MRG;Ho CM;Sreenu VB;Wenham HA;Merritt A;Strang BL
通讯作者：
Strang BL

The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake.

DOI：
10.1073/pnas.2306420120
发表时间：
2023-07-25
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Alder, Arne;Sanchez, Cecilia P.;Russell, Matthew R. G.;Collinson, Lucy M.;Lanzer, Michael;Blackman, Michael J.;Gilberger, Tim-Wolf;Matz, Joachim M.
通讯作者：
Matz, Joachim M.

Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction.