OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

臭氧化学和化学致癌作用

• 批准号: 3249654
• 负责人: ROBERT W MURRAY
• 金额: $ 9.3万
• 依托单位: UNIVERSITY OF MISSOURI-ST. LOUIS
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-03-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3249654
• 关键词: air pollution; alkylating agents; carbonyl compound; carbopolycyclic compound; chemical carcinogenesis; chemical models; chemical reaction; cycloalkene; environment related neoplasm /cancer; environmental contamination; environmental toxicology; ethylene oxide; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; oxygenases; ozone; thin layer chromatography

We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis. We will conduct physical organic studies on carbonyl oxides and dioxiranes in order to determine the electronic, steric, and stereochemical requirements for solution reactions of these two classes of organic peroxides. We will also carry out separate gas phase reactions of carbonyl oxides and dioxiranes with representative polycyclic aromatic hydrocarbons which have been absorbed on model particulate materials. The products of these reactions will be isolated by TLC, GPC and HPLC methods and then identified. In the case of dioxiranes, which are yellow-colored and hence subject to photolysis under ambient atmospheric conditions, some photochemical studies will also be carried out both in solution and the gas phase. The reactions requiring dioxiranes will take advantage of a newly discovered technique which permits preparation of solutions of pure dioxiranes. These combined studies will permit us to assess the separate potential for atmosphere activation of PAH by carbonyl oxides, dioxiranes, and ozone. This assessment in turn is related to the possible atmospheric formation of mutagens/carcinogens by these three chemical agents.

我们建议继续研究臭氧基本的有机化学 以及这种化学与环境健康与环境健康的关系 特别强调诱变和癌变。 我们将对羰基氧化物和二氧烷的物理有机研究 为了确定电子，空间和立体化学 对这两类有机的溶液反应的要求 过氧化物。 我们还将进行羰基的单独气相反应 氧化物和二氧烷含有代表性的多环芳族烃 已在模型颗粒物材料上吸收。 产品的产品 这些反应将通过TLC，GPC和HPLC方法分离，然后 确定。 以黄色的二氧酸性为例，因此 在环境大气条件下进行光解，有些 还将在溶液和气体中同时进行光化学研究 阶段。 需要二氧酸的反应将利用新的优势 发现的技术，允许准备纯的解决方案 二氧化异烷。 这些合并的研究将使我们能够评估单独的潜力 羰基氧化物，二恶英和臭氧对PAH的大气激活。 该评估反过来与可能形成的大气形成有关 这三种化学剂的诱变剂/致癌物。