OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

臭氧化学和化学致癌作用

• 批准号: 2377897
• 负责人: ROBERT W MURRAY
• 金额: $ 15.39万
• 依托单位: UNIVERSITY OF MISSOURI-ST. LOUIS
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2377897
• 关键词: air pollution; alkenes; carbonyl compound; carbopolycyclic compound; chemical carcinogenesis; chemical models; chemical reaction; chemical synthesis; environment related neoplasm /cancer; environmental contamination; environmental toxicology; epoxides; ethylene oxide; mutagens; nuclear magnetic resonance spectroscopy; oxidizing agents; ozone; photochemistry

We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis. Our specific aims include studying basic ozone chemistry and the chemistry of the ozone-derived oxidants, carbonyl oxides and dioxiranes. PAH's absorbed on model particulates will be exposed to a gas stream containing: 1) ozone and 2) an ozone-alkene reaction mixture. Differences in product distributions in these two types of reactions will indicate reactions between the PAH's and ozone-derived oxidants. The presence of arene oxides in the ozone-alkene experiments could be related to the production of mutagens/carcinogens in polluted atmospheres. The nature of the responsible oxidant (carbonyl oxide or dioxirane) will be determined. Ozonolysis of solutions of tetra-substituted alkenes at varying concentration will be studied for evidence of dioxirane formation. Improved methods for the synthesis of dioxiranes will be sought. The reactions of dioxiranes with saturated hydrocarbons will be studied under a variety of reaction conditions. Solvent effects on the rate of epoxidation by dioxiranes will be measured.

我们建议继续研究臭氧的基础有机化学 以及该化学物质与环境健康的关系 特别强调诱变和致癌作用。 我们的具体目标包括研究基础臭氧化学和化学 臭氧衍生氧化剂、羰基氧化物和二氧杂环己烷。 多环芳烃 吸收在模型颗粒上的颗粒将暴露于含有以下成分的气流中： 1) 臭氧和2) 臭氧-烯烃反应混合物。 产品差异 这两类反应的分布将表明反应 多环芳烃和臭氧衍生氧化剂之间。 芳烃氧化物的存在 在臭氧-烯烃实验中可能与 污染大气中的诱变剂/致癌物。 的性质 将确定负责的氧化剂（羰基氧化物或二环氧乙烷）。 四取代烯烃溶液在不同温度下的臭氧分解 将研究浓度以寻找双环氧乙烷形成的证据。 将寻求改进的二环氧乙烷合成方法。 这 将在以下条件下研究二氧杂环己烷与饱和烃的反应 多种反应条件。 溶剂对环氧化速率的影响 将测量二氧杂环丙烷。