The Human Ageing Genomic Resources

人类衰老基因组资源

基本信息

批准号：
BB/R014949/1
负责人：
Joao Magalhaes
金额：
$ 68.19万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FR014949%2F1
关键词：
Human Ageing Genomic Resources

项目摘要

Ageing is a major biomedical challenge of the 21st century and research on the biology and genetics of ageing has an unparalleled potential to improve quality of life and health. The Human Ageing Genomic Resources (HAGR) are a collection of online databases and tools designed to assist basic research on ageing. This project aims to maintain, update and enhance HAGR to sustain its world-leading status and continue serving the scientific community with high-quality data.In a remarkable series of recent breakthroughs, a number of genes capable of altering the ageing process have been identified in animal models and even a few in humans. This is a fascinating and important area of research, yet there is a tremendous number of genes being associated with ageing and longevity that keeping track of them all is becoming increasingly difficult. To help researchers address these issues we created various databases of genes related to longevity and/or ageing. Numerous researchers employ our gene databases in their work as an informational website and/or as a tool for data-mining and for interpreting experimental results.Although finding mechanisms of ageing conserved between model organisms and humans is important, the diversity of ageing rates between similar species is remarkable. Understanding why different species age at different rates may provide key insights into the mechanisms of human ageing. Also part of HAGR is a database of ageing in animals with over 4,000 species, featuring the most accurate and complete collection of longevity records available in any format. Our database is an essential resource for researchers working on comparative and evolutionary studies of ageing to identify factors or features that correlate with species longevity.The HAGR databases are widely-used by ageing researchers worldwide and have been invaluable in many different types of studies. Indeed, HAGR has been cited over 500 times. Besides, our online resources receive over 30,000 visitors per month, showcasing HAGR's importance in the field. All HAGR databases are open access and also provide users with the possibility to export, download and reuse the data for their own analyses.

衰老是21世纪的主要生物医学挑战，对衰老的生物学和遗传学的研究具有改善生活质量和健康的无与伦比的潜力。人类衰老的基因组资源（HAGR）是旨在帮助基础研究衰老的在线数据库和工具的集合。该项目旨在维护，更新和增强HAR，以维持其世界领先地位，并继续使用高质量的数据为科学界服务。在一系列了不起的一系列突破中，许多能够改变衰老过程的基因在动物模型中已经确定，甚至在人类中甚至有一些。这是一个有趣而重要的研究领域，但是有大量基因与衰老和寿命相关，可以跟踪它们都变得越来越困难。为了帮助研究人员解决这些问题，我们创建了与寿命和/或衰老有关的各种基因数据库。许多研究人员将我们的基因数据库作为信息网站和/或作为数据挖掘和解释实验结果的工具。尽管查找模型有机体和人类之间保守衰老的机制是重要的，但相似物种之间衰老率的多样性非常重要。了解为什么以不同速率的不同物种年龄可以为人类衰老机制提供关键的见解。 HAGR的一部分也是一个超过4,000种动物的衰老数据库，其寿命记录最准确，最完整的寿命记录以任何格式可用。我们的数据库是研究衰老比较和进化研究的研究人员的重要资源，以识别与物种寿命相关的因素或特征。在全球范围内，衰老的研究人员广泛使用了HAGR数据库，并且在许多不同类型的研究中都是无价的。确实，HAR被引用了超过500次。此外，我们的在线资源每月将获得超过30,000名访客，展示了Hagr在该领域的重要性。所有HAGR数据库都是开放访问权限，还为用户提供了导出，下载和重复数据进行分析的可能性。