ConBioChem: Continuous bio-production of commodity chemicals

ConBioChem：大宗化学品的连续生物生产

基本信息

批准号：
BB/N023773/1
负责人：
Alex Conradie
金额：
$ 200.85万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FN023773%2F1
关键词：
ConBioChem Continuous bio production commodity

项目摘要

The current slump in oil prices should not lead us to ignore the fact that, in the future, an ever-increasing proportion of the fuels and chemicals, required for everything from jumbo jets to toy elephants, will need to come from renewable resources. This means a huge expansion of the fermentation industry, and the cost of the required manufacturing plant will rapidly become unaffordable. The solution is to move from performing fermentations batchwise (like manufacturing cars one at a time) to continuous processes (like an automobile production line). This major change presents a number of challenges in engineering production microbes, and in designing and controlling the industrial processes in which they operate. This project aims to produce a pipeline that will meet all of these challenges in an integrative manner. It will result in stable and robust production microbes in which there is an optimal balance between the growth of the process microorganism and formation of the industrial product that it generates. The new microbes will be exploited in new continuous processes, and process controls will be developed in which the microbe is 'rewarded' with nutrients for generating high levels of the industrial product. Such a 'control by incentives' strategy will, in itself, contribute to the stability of the production organism. The environmental impacts of the new processes will be assessed to ensure that they are cleaner and greener than the chemical processes that they are replacing. Lastly, the costs of building new factories to manufacture the chemicals will be assessed, together with the costs of operating them, to ensure that the new continuous bio-manufacturing processes will be profitable for UK companies.

目前的油价低迷不应导致我们忽略这样一个事实，即将来，从巨型喷气机到玩具大象所需的一切燃料和化学药品的比例不断增加，需要来自可再生资源。这意味着发酵行业的巨大扩展，所需的制造工厂的成本将迅速变得无法承受。解决方案是从进行易发酵（例如一次制造汽车）转变为连续过程（例如汽车生产线）。这一重大变化在工程生产微生物以及设计和控制其运营的工业过程方面提出了许多挑战。该项目旨在生产一条管道，该管道将以整合的方式应对所有这些挑战。它将导致稳定而强大的生产微生物，在这种微生物中，过程微生物的生长与其产生的工业产品的形成之间存在最佳平衡。新的微生物将在新的连续过程中被利用，并将开发过程控制，其中微生物“奖励”了营养，以产生高水平的工业产品。这种“激励措施”策略本身将有助于生产生物的稳定性。将评估新过程的环境影响，以确保它们比要替代的化学过程更清洁和绿色。最后，建立新工厂制造化学品的成本将被评估，以及运营它们的成本，以确保新的连续生物制造过程对英国公司来说将是有利可图的。