WATER FLUORIDATION AND FRACTURES IN OLDER WOMEN

老年女性的水氟化和骨折

• 批准号: 3224105
• 负责人: KATHY R. PHIPPS
• 金额: $ 10.37万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3224105
• 关键词: aging; bone density; bone fracture; female; fluoridation; frail elderly; hip fractures; human subject; human therapy evaluation; osteoporosis; skeletal disorder chemotherapy

For the past 45 years, there has been a great deal of debate regarding the health issues surrounding the fluoridation of public water supplies. Recent ecological studies demonstrating a positive association between fluoridation and hip fracture have rekindled the debate (Jacobsen et al., Danielson et al.). Both of these studies, however, were conducted at the aggregate level and are subject to the ecologic fallacy. In order to accurately evaluate the association between community water fluoridation and osteoporotic fractures, research must be conducted on the individual level where confounders such as hormone replacement therapy and actual fluoride exposure can be measured. The purpose of this study is to evaluate the association between fluoridation and osteoporotic fractures while controlling for all known confounding variables. The study population will consist of women enrolled in the NIH supported multi- center Study of Osteoporotic Fractures (SOF). During 1986-88, slightly more than 9,700 women (greater than or equal to 65 years) were enrolled in the SOF study at four sites; Portland, OR; the Monogahela Valley, PA; Baltimore, MD; and Minneapolis, MN. Approximately 7,500 women have taken part in four extensive examinations over a five-year period. The SOF database contains information on all known confounding variables, bone mineral density at multiple sites, and fracture rates. The database for the Monogahela Valley also contains information on fluoride exposure via water systems for each of the participants from 1950-1990. During the course of this study, data on fluoride exposure from water systems will be gathered from the women participating in SOF at the Portland, Baltimore, and Minneapolis study sites. Baltimore and Minneapolis have been fluoridated since 1952 and 1957 respectively, while Portland and the majority of the Monongahela Valley are not fluoridated. The primary goal of the study will be to determine if fluoride exposure status is associated with fracture incidence rates, bone mineral density, and/or the rate of bone loss on the individual level once confounding variables are controlled for. Given that the USPHS promotes fluoridation of water at 1.0 ppm to prevent dental caries, the effect of consuming such water on osteoporotic changes needs to be clarified.

在过去的45年中，关于 围绕公共供水的氟化的健康问题。 最近的生态研究表明 氟化和髋部骨折重新点燃了辩论（Jacobsen等， Danielson等人）。 但是，这两项研究均在 总水平，并受到生态谬误的影响。 为了 准确评估社区水氟化之间的关联 和骨质疏松性骨折，必须对个体进行研究 诸如激素替代疗法和实际的混杂因素的水平 可以测量氟化物的暴露。 这项研究的目的是 评估氟化与骨质疏松性裂缝之间的关联 在控制所有已知的混杂变量的同时。 研究 人口将包括参加NIH支持的妇女 骨质疏松骨折（SOF）的中心研究。 在1986 - 88年期间 招募了9,700多名妇女（大于或等于65年） 在四个地点的SOF研究中；俄勒冈州波特兰；宾夕法尼亚州的Monogahela山谷； 马里兰州巴尔的摩；和明尼苏达州明尼阿波利斯。 大约有7,500名妇女 在五年内进行四次大规模考试。 SOF 数据库包含有关所有已知混杂变量，骨骼的信息 多个位置的矿物质密度和断裂率。 数据库 Monogahela山谷还包含有关通过 1950 - 1990年每个参与者的供水系统。 在 在这项研究的过程中，关于氟化物暴露于水系统的数据将 从参加波特兰的SOF的妇女聚集 巴尔的摩和明尼阿波利斯研究地点。 巴尔的摩和明尼阿波利斯有 自1952年和1957年分别氟化，波特兰和 Monongahela山谷的大多数没有氟化。 主要目标 该研究将是确定氟化物暴露状态是否为 与断裂发生率，骨矿物质密度和/或 一旦混淆变量 被控制。 鉴于USPHS促进了水的氟化 以1.0 ppm以防止龋齿，消耗这种水的影响 关于骨质疏松的变化需要澄清。