WATER-BORNE FLUORIDE AND BONE MINERAL DENSITY

水性氟化物和骨矿物质密度

• 批准号: 3223681
• 负责人: KATHY R. PHIPPS
• 金额: $ 23.12万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3223681
• 关键词: bone density; community dental health; dental survey; fluoridation; human old age (65+); human subject; interview; longitudinal human study; osteopenia; photon absorptiometry; public health; statistics /biometry; water treatment

DESCRIPTION (adapted from the Investigator's abstract):It has been postulated that community water fluoridation may prevent skeletal bone loss and reduce the risk of osteoporotic fractures. However, data to support this hypothesis are not available. Three recent studies indicate that women living in communities with 4.0 ppm fluoride in the water system have lower levels of cortical bone and an increased risk of fracture when compared to women living in communities with 1.0 ppm fluoride. Another study indicates that both women and men living in areas with fluoridated water systems are at higher risk of hip fractures than those living in areas with negligible levels of fluoride in the drinking water. The purpose of the proposed study is to clarify the relationship between varying levels of water-borne fluoride and osteopenia as measured by decreased bone mineral density in adults aged 60 or older. Data will be collected on long-term residents of three similar communities in eastern Oregon and Washington. The communities have water fluoride levels of 0.06, 1.0, and 2.5 ppm. Approximately 105 women and 105 men in each of the three communities will be interviewed regarding known confounding variables and have their bone density evaluated via dual energy x-ray absorptiometry. The data will be analyzed to investigate whether bone mineral density differs between the three fluoride levels, when the density is adjusted statistically for values of the confounding variables. Evidence would be provided about whether people consuming fluoridated water have a different level of bone mineral density, which has important implications in regard to the existing public policy of community water fluoridation.

描述（改编自调查人员的摘要）： 假定社区水氟化可能会阻止骨骼骨骼 损失并降低骨质疏松骨折的风险。 但是，数据到 支持此假设不可用。 最近的三项研究表明 居住在水中氟化物4.0 ppm的社区中的妇女 系统具有较低的皮质骨，并且有增加的风险 与居住在1.0 ppm社区的妇女相比，断裂 氟化物。 另一项研究表明，居住在 氟化水系统的区域髋部骨折风险更高 比居住在氟化物水平可忽略的地区的 饮用水。 拟议的研究的目的是澄清 氟化物水平变化的关系与 通过骨矿物质密度降低，成年人的骨质减少症 60岁或以上。 数据将收集到三个的长期居民 俄勒冈州东部和华盛顿的类似社区。 社区 氟化物水平为0.06、1.0和2.5 ppm。 大约105 三个社区中每个社区中的每个男人和105名男子将接受采访 关于已知的混杂变量并具有骨密度 通过双能X射线吸收法评估。数据将进行分析 研究骨矿物质密度是否有所不同 氟化物水平，当密度统计上调整密度时 混杂变量。将提供有关是否的证据 食用氟化水的人具有不同的骨矿物质 密度，对现有的重要含义 社区水氟化的公共政策。