NASAL AIRWAY AND RESPIRATORY MODE IN CLEFT PALATE

腭裂的鼻气道和呼吸模式

• 批准号: 3220469
• 负责人: DONALD W WARREN
• 金额: $ 16.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3220469
• 关键词: cleft lip; cleft palate prosthesis; human subject; human therapy evaluation; oral facial restoration; oral pharyngeal surgery; plastic surgery; plethysmography; respiratory airflow disorder; respiratory airflow measurement

Clefts of the lip and palate often result in significant nasal deformities which tend to reduce the size of the nasal airway. Similarly, surgical procedures to correct nasal asymmetry, palatal incompetency or maxillary deficits can also impair nasal breathing. A number of clinicians have suggested that impairment of nasorespiratory function influences dentofacial growth; others disagree. The controversy stems from our inability to define airway impairment quantitatively and assess mouthbreathing objectively. In cleft palate, the emphasis has been on esthetics and speech with little concern for airway patency in spite of the fact that treatment can compromise the upper airway. The specific aims of this research are to use newly developed quantitative techniques to: 1. determine how the nasal airway of cleft lip/palate individuals differs from normals, 2. evaluate the effects of physical management on the cleft nasal airway, 3. assess the effects of cleft lip/palate on nasal and oral breathing, 4. define nasal airway impairment in children, and 5. determine how the respiratory system responds to airway impairment. Recent advances in respiratory technology provide the opportunity to quantitatively assess breathing in this group of patients. Such information could be critical for decisions relating to physical management. One approach will be to measure nasal airway size using a technique developed by Warren for speech research. The other technique is a non-invasive method for measuring oral-nasal respiration. Finally, body plethysmography will be used to measure airway resistance throughout the respiratory tract. This research represents a new direction in the objective quantification of upper airway breathing and airway impairment in the cleft and normal populations. The results are expected to provide needed information concerning the immediate and long-term effects of physical management. Since impairment has been implicated as contributing to growth disturbances, it is especially important to determine the extent of this in a population which already demonstrates tissue deficiencies, distortions, and displacement problems. Additionally, these studies concern breathing as a regulating system phenomenon, an area that appears promising in terms of understanding how the body responds both morphologically and physiologically to airway impairment.

唇裂和腭裂通常会导致严重的鼻部畸形 这往往会缩小鼻气道的大小。 同样，手术 矫正鼻不对称、腭功能不全或上颌骨不对称的手术 缺陷也会损害鼻呼吸。 许多临床医生已经 表明鼻呼吸功能受损会影响 牙面生长；其他人不同意。 争议源于我们 无法定量定义气道损伤并评估 客观地用嘴呼吸。 在腭裂中，重点是 尽管有美感和言语，但很少关心气道通畅 事实上，治疗可能会损害上呼吸道。 本研究的具体目标是使用新开发的定量方法 技术： 1. 确定唇裂/腭裂的鼻气道如何 个体与正常人不同，2.评估身体的影响 鼻气道裂的处理，3.评估裂隙的影响 唇/腭对鼻和口呼吸的影响，4. 定义鼻气道损伤 5. 确定儿童呼吸系统对气道的反应 损害。 呼吸技术的最新进展提供了机会 定量评估该组患者的呼吸情况。 这样的 信息对于与物理相关的决策可能至关重要 管理。 一种方法是使用测量鼻气道尺寸 沃伦开发的用于语音研究的技术。 另一种技术是 一种测量口鼻呼吸的非侵入性方法。 最后是本体 体积描记法将用于测量整个气道阻力 呼吸道。 这项研究代表了客观量化的新方向 裂隙和正常的上呼吸道呼吸和气道损伤 人口。 结果预计将提供所需的信息 关于身体管理的近期和长期影响。 由于减值被认为有助于增长 扰，确定扰动的程度尤为重要 一个已经表现出组织缺陷、扭曲的人群， 和位移问题。 此外，这些研究还涉及呼吸 作为一种调节系统现象，一个看起来很有前途的领域 了解身体如何在形态和形态上做出反应 生理上气道损伤。