EFFECTS OF SO2 AND RESPIRABLE PARTICULATES ON HEALTH

SO2 和可吸入颗粒物对健康的影响

• 批准号: 3249494
• 负责人: BENJAMIN G FERRIS
• 金额: $ 230.02万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1974
• 资助国家: 美国
• 起止时间: 1974-06-29 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3249494
• 关键词: adult human (21+); aerosols; air pollution; air sampling /monitoring; data collection methodology /evaluation; environmental contamination; environmental toxicology; fluorescence spectrometry; health surveys; housing; human age group; human ecology; human morbidity; ion exchange chromatography; longitudinal human study; lung; middle childhood (6-11); nitrous oxide; particle; pollutant interaction; pollution related respiratory disorder; psychophysiology; respiratory disorder epidemiology; respiratory function; respiratory infections; spirometry; statistics /biometry; sulfates; sulfites; sulfur oxides; urban area

The proposed research will continue a multidisciplinary prospective study of the effects of outdoor and indoor air pollutants on pulmonary function and respiratory disease during childhood and adult life. Enrollment of 13,853 children and 8,859 adults began in six eastern and midwestern cities between 1974 and 1977, accompanied by an extensive air quality monitoring program of both outdoor and indoor environments. The children have been seen annually and the adults every three years. The data are currently complete through the 1980-81 examination. The proposed research will include continued analysis of data collected prior to 1 July 1983: a) In children, to describe the development of pulmonary function and age-specific respiratory illness rates between 6 and 13 years of age and the effects of air pollution on these changes. b) In adults, to describe the effects of air pollutants on changes over 6 years in pulmonary function and respiratory morbidity. c) To relate the mortality of adults during 6-year follow-up to baseline pulmonary function, respiratory morbidity, and air pollution exposures. d) In adults and children, to relate short-term changes in pulmonary function to daily fluctuations in air quality. e) To analyze data collected from indoor and outdoor monitoring and personal exposure studies to develop indices of personal exposure to air pollutants that will refine our health effects analyses. Annual examinations of participating children will be continued until high school graduation or age 18 to investigate the development of pulmonary function through adolescence and the effects of previous exposure to air pollutants and the onset of cigarette smoking on that development. An additional cohort of third- and fourth-grade children will be enrolled in each city to investigate the health significance of changes in air quality in participating cities since the start of the study. Participating adults will be followed for current address and vital status. Air pollution monitoring will continue at a central site in each city. To develop better estimates of personal exposure, the indoor environments of 200 homes in each community will be studied. More detailed analyses and characterization of the aerosols in each city are projected.

拟议的研究将继续进行多学科前瞻性研究 室外和室内空气污染物对肺功能的影响 以及儿童期和成年期的呼吸道疾病。 报名人数 13,853 名儿童和 8,859 名成人在东部和中西部的六个城市开始 1974年至1977年间，伴随着广泛的空气质量监测 室外和室内环境的程序。 孩子们已经 每年见一次，成人每三年见一次。 目前数据为 完成1980-81年考试。 拟议的研究将 包括对 1983 年 7 月 1 日之前收集的数据进行持续分析： 儿童，描述肺功能的发展和 6 至 13 岁之间特定年龄的呼吸道疾病发病率 空气污染对这些变化的影响。 b) 在成人中，描述 6年来空气污染物对肺功能变化的影响 和呼吸道疾病。 c) 将成年人的死亡率联系起来 对基线肺功能、呼吸系统发病率和病情进行 6 年随访 空气污染暴露。 d) 对于成人和儿童，将短期联系起来 肺功能的变化与空气质量的日常波动有关。 e) 至 分析从室内和室外监控和个人收集的数据 暴露研究以制定个人空气污染物暴露指数 这将完善我们的健康影响分析。 年度考试 参与的儿童将持续到高中毕业或 18 岁通过以下方式调查肺功能的发展情况 青春期以及之前接触空气污染物的影响和 吸烟的开始与这一发展有关。 另一个队列 三四年级的孩子将在每个城市入学 研究空气质量变化对健康的意义 自研究开始以来参与城市。 参加成人 将跟踪当前地址和生命状况。 空气污染 监控将在每个城市的中心站点继续进行。 为了更好的发展 对个人接触量的估计，200个家庭的室内环境 每个社区都将受到研究。 更详细的分析和 预测每个城市气溶胶的特征。