MARIJUANAN DURING PREGNANCY: NEUROBEHAVIORAL EFFECTS

怀孕期间吸食大麻：神经行为影响

• 批准号: 3208034
• 负责人: DONALD E HUTCHINGS
• 金额: $ 10.45万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3208034
• 关键词: albino rat; amphetamines; animal developmental psychology; blood chemistry; body composition; cannabinoids; chordate locomotion; developmental neurobiology; developmental nutrition; dosage; eating; embryo /fetus death; embryo /fetus drug adverse effect; neuropsychology; neurotransmitter metabolism; nutrition related tag; postnatal growth disorder; startle reaction

The present proposal represents a comprehensive multidisciplinary approach to the study of prenatal exposure to delta-9- tetrahydrocannabinol (THC) using the laboratory rat. Four experienced investigators in the fields of developmental toxicology/teratology, developmental psychobiology, developmental nutrition, and cannabinoid pharmacology will study a wide range of developmental outcomes resulting from prenatal exposure to THC. These studies represent a logical progression in a research program initiated in 4/83 and include the effects of prenatal THC on the following outcomes: 1) the study of in utero and perinatal female lethality to determine the developmental period when death occurs, 2) dose-response studies to better describe delayed growth and catch-up, 3) pharmacological studies of the postnatal persistence of THC in a variety of offspring tissues and possible correlation with growth inhibition, 4) measures of milk consumption and suckling efficiency and their relationship to growth, 5) studies of qualitative changes in body composition durign postnatal growth, and 6) possible long-term effects in adult offspring including a) locomotor activity with and without amphetamine challenge and b) reflex startle with and without THC challenge. We hope the results of this programmatic research will increase our knowledge of the developmental toxicity of THC during pregnancy and provide useful scientific information with respect to the prenatal hazard of THC exposure in the human population.

本提案代表了一个全面的多学科 研究产前暴露于delta-9--的方法 使用实验室大鼠的四氢大麻酚（THC）。 四个 在发展领域的经验丰富的调查员 毒理学/替代性，发展心理生物学， 发育营养和大麻素药理学将研究 产前产生的广泛发展结果 暴露于THC。 这些研究代表了逻辑进展 一个以4/83启动的研究计划，包括 产前THC以下结果：1）在子宫内的研究 和围产期女性致死性以确定发育 发生死亡的时期，2）剂量反应研究以更好 描述延迟生长和追赶，3）药理研究 多种后代的产后持久性 组织和可能与生长抑制的可能相关性，4） 牛奶消耗和哺乳效率及其 与增长的关系，5）对身体定性变化的研究 组成堤防产后生长和6）可能的长期 在成人后代的影响，包括a）与和 没有苯丙胺挑战，b）反射会惊吓和 没有THC挑战。 我们希望这个程序化的结果 研究将增加我们对发展的了解 怀孕期间THC的毒性并提供有用的科学 有关THC暴露的产前危害的信息 在人口中。