STATISTICAL METHODLOGY FOR STUDY OF THE AIDS EPIDEMIC

艾滋病流行研究的统计方法

• 批准号: 3210381
• 负责人: DONALD L THOMSEN
• 金额: $ 89.01万
• 依托单位: SOCIETAL INSTITUTE OF THE MATH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210381
• 关键词: AIDS; AIDS /HIV diagnosis; Australia; British Isles; CD4 molecule; Canada; Germany; HIV infections; United States; biomarker; communicable disease transmission; computer data analysis; computer program /software; disease /disorder proneness /risk; epidemiology; hepatitis B; human subject; intravenous drug abuse; mathematical model; mathematics; model design /development; sex behavior; statistics /biometry

The objective of this project is the continued development and evaluation of statistical methods for use in research related to drug use and the Acquired Immuno-deficiency Syndrome (AIDS). A collaborative team drawn from five university centers will undertake research studies to respond to the need to provide information on the AIDS epidemic which makes full use of available data. Statistical methods which allow description of the time-dependent multifactorial aspects of the natural history of AIDS will be developed and applied to data on intravenous (IV) drug abusers who are infected with the human immunodeficiency virus (HIV). Relative risk regression models will provide a methodologic framework for this research. Topics of specific interest will be (i) the development of models for immunological markers of HIV disease and their relationship to clinical outcomes in IV drug abusers, (ii) estimation of the time of HIV infection and the probability of developing AIDS after infection in IV drug abusers, (iii) estimation of seroprevalence and incidence in IV drug abusers, (iv) models for studying the role of cofactors that affect vulnerability and transmissibility of HIV, (v) mathematical modeling of AIDS risk and transmission among IV drug abusers and the heterosexual population. Other areas to be considered include AIDS case projection methodology, analysis of correlated categorical data and work on data from international sources. Furthermore the analysis of data arising from studies of AIDS in the research centers will continue to direct research focus as well as provide the opportunity to test methods and computer software which are developed as part of this research.

该项目的目的是持续的发展和 评估与药物有关的研究中使用的统计方法 使用和获得的免疫缺陷综合征（AIDS）。 协作 五个大学中心的团队将进行研究 应对提供有关艾滋病流行的信息的需求 充分利用可用数据。 统计方法允许 自然时间依赖时间的多因素方面的描述 艾滋病的历史将被开发并应用于静脉注射的数据 （iv）感染人类免疫缺陷病毒的毒品滥用者 （艾滋病病毒）。 相对风险回归模型将提供一种方法论 这项研究的框架。 特定兴趣的主题将是（i） 开发艾滋病毒疾病的免疫学标记模型和 它们与静脉滥用者的临床结果的关系，（ii） 艾滋病毒感染时间的估计和 在静脉注射药物中感染后开发艾滋病，（iii）估计 静脉注射药物的血清阳性和发病率，（iv）模型 研究影响脆弱性和 艾滋病毒的传播性，（v）艾滋病风险的数学建模和 静脉滥用者和异性恋人群之间的传播。 需要考虑的其他领域包括艾滋病案例投影方法， 分析相关的分类数据并从 国际资源。 此外，对数据产生的数据分析 研究中心的艾滋病研究将继续指导研究 重点以及提供测试方法和计算机的机会 作为本研究的一部分开发的软件。