DOSE COMPARISON OF STEREOTACTIC RADIOSURGICAL MODALITIES

立体定向放射外科手术方式的剂量比较

• 批准号: 3195713
• 负责人: Mark H. Phillips
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3195713
• 关键词: combination cancer therapy; disease /disorder model; head /neck neoplasm; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; particle accelerators; proton beam; radiation therapy dosage; skull; stereotaxic techniques

Different techniques of small field stereotaxic external beam radiotherapy, also known as stereotactic radiosurgery, or intracranial lesions will be compared by means of dose distributions calculated using a CT-based, 3- dimensional treatment planning computer program. Radiosurgical treatment of intracranial tumors and vascular malformations has proven to be a very successful means of curing life-threatening and debilitating lesions in thousands of patients. These results have been achieved by a small number of radiosurgical modalities with specific treatment protocols. Recently, a number of new radiosurgical modalities have been implemented or proposed, and the use of these techniques is spreading rapidly. In order to evaluate different radiosurgical modalities, a systematic comparison of dose distributions will be performed, and the results evaluated by means of dose-volume histograms. Radiation types that will be studied are charged particles (protons, helium ions, carbon ions, and neon ions) and photons (Co 60 gamma-rays and megavoltage photons from linear accelerators). Irradiation geometries (the number, orientation, and weighting of beamports) that will be studied are the currently-used charged particle methods at Lawrence Berkeley Laboratory (LBL) and the Harvard Cyclotron, the Co 60 Gamma Knife, and a number of Linac-based rotational arc methods, including the methods used in Heidelberg, Boston, and Montreal. The dose to the target volume and to regions of normal tissue will be compared. The effects of the target size, shape, and location on the patterns of dose distribution will be studied in order to determine classes of lesions best treated by particular radiosurgical methods. Use will be made of clinical data at LBL in order to help determine dose-volume relationships of clinical effects.

小场立体定位外束放疗的不同技术， 也称为立体定向放射外科或颅内病变将是 通过使用基于CT的3-计算的剂量分布进行比较 维处理计划计算机计划。 放射外科治疗 事实证明，颅内肿瘤和血管畸形已被证明是一个非常 成功地治愈生命的方法 成千上万的患者。 这些结果是通过少量实现的 具有特定治疗方案的放射外科方式。 最近， 已经实施或提出了许多新的放射外科方式， 这些技术的使用正在迅速传播。 为了评估 不同的放射外科方式，剂量的系统比较 将执行分布，并通过 剂量体积直方图。 将收取将研究的辐射类型 颗粒（质子，氦离子，碳离子和霓虹灯离子）和光子 （CO 60伽马射线和来自线性加速器的巨型光子）。 辐照几何形状（数量，方向和加权 将研究的beamports）是当前使用的充电粒子 劳伦斯·伯克利实验室（LBL）和哈佛大学的方法， CO 60伽马刀和许多基于Linac的旋转弧方法， 包括海德堡，波士顿和蒙特利尔使用的方法。 剂量 将比较目标体积和正常组织的区域。 这 目标大小，形状和位置对剂量模式的影响 将研究分布以确定最佳病变类 通过特定的放射外科方法处理。 将使用临床 LBL的数据以帮助确定 临床效果。