HEMATOLYMPHOPOIETIC MALIGNANCIES IN ITALY

意大利的造血淋巴细胞恶性肿瘤

• 批准号: 2094108
• 负责人: PAOLO VINEIS
• 金额: $ 19.53万
• 依托单位: UNIVERSITA DI TORINO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2094108
• 关键词: Hodgkin's disease; Italy; blood /lymphatic neoplasm; cancer risk; case history; chemical carcinogen; chemical related neoplasm /cancer; cytogenetics; environment related neoplasm /cancer; environmental toxicology; female; herbicides; histochemistry /cytochemistry; human population study; human subject; immunochemistry; interview; ionizing radiation; leukemia; longitudinal human study; lymphoma; male; mathematical model; multiple myeloma; occupational hazard; questionnaires; solvents; statistics /biometry; work site

Exposures to organic solvents (including benzene), ionizing radiation and low-frequency electromagnetic fields have been suggested as risk factors for leukemias in adults. Exposure to herbicides of the phenoxyacid variety (2,4,5-T; 2,4-D) has been reported to be associated with an increased risk of non-Hodgkin's lymphomas. In addition, several studies have suggested that agricultural workers have an excess risk of hemato- lymphopoietic malignancies, although no specific agent has yet been identified. Italy is particularly attractive for investigating further these associations, because: a) there is a high prevalance of exposure to solvents in industrial areas (estimated to be 10-16% in the provinces of Torino, Varese and Firenze), and a high prevalence of exposure to herbicides (including phenoxyacids) in agricultural areas; b) there is also considerable extra-occupational exposure to solvents and pesticides; c) competent groups of hematologists exist in several towns, using advanced diagnostic techniques including cytogenetics. We propose therefore to conduct a multicenter population-based case-control study in 12 Italian areas, chosen on the basis of a high exposure prevalence. In three years, we intend to interview approximately 1060 cases of leukemia, 1880 cases of lymphoma (Hodgkin and non-Hodgkin) and 400 cases of myeloma; 2000 randomly selected individuals, residents of the same areas, will serve as a population control group. Cases will be all those occurring in the study period among residents of the 12 areas, newly diagnosed. Particular care will be dedicated to diagnostic aspects, including B- and T-cell characterization and, in four of the areas, cytogenetics using banding techniques. Cases and controls will be blindly interviewed by trained personnel. The occupational histories will be blindly evaluated by industrial hygienists and agronomists, in order to assess the probability of exposure to organic solvents, phenoxy herbicides and other chemicals. The study will have a statistical power of 90% to detect a relative risk of 2.0 for the associations between organic solvent exposure and leukemias and between herbicide exposure and non-Hodgkin's lymphomas in men (p=0.05).

暴露于有机溶剂（包括苯），电离辐射和 低频电磁场已被认为是风险因素 成人白血病。 暴露于苯乙酸的除草剂 据报道，品种（2,4,5-T; 2,4-D）与 非霍奇金淋巴瘤的风险增加。 另外，一些研究 已经提出，农业工作者有肿瘤的过多风险 淋巴管恶性肿瘤，尽管尚无特定代理 确定。 意大利对于进一步调查特别有吸引力 这些关联，因为：a）暴露率很高 到工业区的溶剂（估计在各省中为10-16％ 地那么高，瓦雷塞和佛兰兹），并且很高的暴露率 农业地区的除草剂（包括苯氧酸）； b）有 还大量的外部暴露于溶剂和农药； c）使用的血液学家群体存在于几个城镇中，使用 晚期诊断技术，包括细胞遗传学。 我们建议 因此进行基于多中心的基于人群的病例对照研究 在12个意大利地区，根据高暴露率选择。 在三年内，我们打算采访大约1060个案例 白血病，1880例淋巴瘤（霍奇金和非霍奇金）和400例 骨髓瘤； 2000个随机选择的人，同一居民 区域将充当人口对照组。 案件将是所有的 在研究期间发生在12个地区的居民之间 诊断。 特别注意诊断方面， 包括B-和T细胞表征，在四个区域中， 使用带技术的细胞遗传学。 案件和控制将是 受过训练的人员盲目采访。 职业历史 将由工业卫生学家和农艺师盲目评估 为了评估暴露于有机溶剂，稳态的可能性 除草剂和其他化学物质。 该研究将具有统计能力 90％以检测2.0的相对风险 有机溶剂暴露和白血病以及除草剂暴露与 男性中非霍奇金的淋巴瘤（p = 0.05）。

项目成果

The role of occupational exposure and immunodeficiency in B-cell malignancies. Working Group on the Epidemiology of Hematolymphopoietic Malignancies in Italy.

职业暴露和免疫缺陷在 B 细胞恶性肿瘤中的作用。

• DOI: 10.1097/00001648-199205000-00014
• 发表时间: 1992
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Vineis,P;D'Amore,F
• 通讯作者: D'Amore,F

Childhood infectious diseases and risk of non-Hodgkin's lymphoma according to the WHO classification: A reanalysis of the Italian multicenter case-control study.

根据世界卫生组织分类，儿童传染病和非霍奇金淋巴瘤的风险：意大利多中心病例对照研究的重新分析。

• DOI: 10.1002/ijc.32393
• 发表时间: 2020
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Parodi,Stefano;SenioriCostantini,Adele;Crosignani,Paolo;Fontana,Arabella;Miligi,Lucia;Nanni,Oriana;Piro,Sara;Ramazzotti,Valerio;Rodella,Stefania;Tumino,Rosario;Vindigni,Carla;Vineis,Paolo;Stagnaro,Emanuele
• 通讯作者: Stagnaro,Emanuele

Does a gene in the Xq28 region increase the risk of non-Hodgkin's lymphomas? Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy.

Xq28 区域的基因是否会增加非霍奇金淋巴瘤的风险？

• DOI: 10.1023/a:1008359604717
• 发表时间: 1999
• 期刊: Annals of oncology : official journal of the European Society for Medical Oncology
• 作者: Vineis,P;Masala,G;Costantini,AS
• 通讯作者: Costantini,AS

Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study.

儿童传染病和多发性骨髓瘤的风险：意大利多中心病例对照研究的分析。

• DOI: 10.1017/s0950268818001413
• 发表时间: 2018
• 期刊: Epidemiology and infection
• 影响因子: 4.2
• 作者: Stagnaro,E;Parodi,S;Costantini,ASeniori;Crosignani,P;Miligi,L;Nanni,O;Piro,S;Ramazzotti,V;Rodella,S;Tumino,R;Vindigni,C;Vineis,P
• 通讯作者: Vineis,P

Genetic-environmental interactions and low-level exposure to carcinogens.

遗传-环境相互作用和低水平接触致癌物。

• DOI: 10.1097/00001648-199507000-00026
• 发表时间: 1995
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Vineis,P;Martone,T
• 通讯作者: Martone,T