13 ERA IB: ANTHOcyanin production PLatform Using Suspension cultures (ANTHOPLUS)

13 ERA IB：使用悬浮培养物的花青素生产平台 (ANTHOPLUS)

• 批准号: BB/M004864/1
• 负责人: Cathie Martin
• 金额: $ 51.52万
• 依托单位: John Innes Centre
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM004864%2F1
• 关键词: 13; ERA; IB; ANTHOcyanin; production

Anthocyanins are water-soluble pigments that colour the fruit and flowers of many plants. More than 635 different anthocyanins have been identified, distinguished by methylation, glycosylation and acylation with both aliphatic and aromatic groups. There is mounting evidence that consumption of anthocyanin-rich food promotes health, supported by many recent studies of anthocyanin-rich fruits such as blueberry, bilberry and cranberry. Their relative abundance in the diet and their potency against a range of chronic diseases have made anthocyanins the subject of intense research in experimental and preventive medicine and, more recently for formulating natural colours. However, the limited range of anthocyanins commercially available and the expense of pure preparations mean that most research is done with crude extracts of plants which are not standardised with respect to the particular anthocyanins they contain, nor the amounts of each anthocyanin in the extract. Variations in anthocyanin decoration account for differences in colour stability and hue of anthocyanins and underpin the need for developing production systems for pure anthocyanins for investigating the effects of chemical specificity on uptake, signalling and physiology, toxicity of anthocyanins for medical applications and for developing new formulations in the natural colours industries. In ANTHOPLUS novel plant cell cultures will be developed for the stable production of a wide variety of anthocyanins. The novel procedure for generating these cultures means that they are not constrained by prior art. Our cell cultures, uniquely, allow sustained, high level production of diverse anthocyanins. Enhanced supplies of pure anthocyanins will be highly valuable for the colourants industry to investigate the effects of decorations, co-pigments, pH on colour and stability to provide a robust scientific foundation for developing new plant sources of natural colourants and new formulations for natural colours.

花青素是水溶性色素，可为许多植物的果实和花朵着色。已鉴定出超过 635 种不同的花青素，通过脂肪族和芳香族基团的甲基化、糖基化和酰化来区分。越来越多的证据表明，食用富含花青素的食物可以促进健康，最近对蓝莓、越橘和蔓越莓等富含花青素的水果进行的许多研究也支持了这一点。花青素在饮食中的含量相对丰富，并且具有对抗一系列慢性疾病的功效，这使得花青素成为实验和预防医学以及最近用于配制天然色素的深入研究的主题。然而，市售花青素的范围有限以及纯制剂的费用意味着大多数研究都是使用植物的粗提取物进行的，这些提取物对于它们所含的特定花青素以及提取物中每种花青素的含量都没有标准化。花青素装饰的变化导致了花青素颜色稳定性和色调的差异，并支持开发纯花青素生产系统的需要，以研究化学特异性对摄取、信号传导和生理学的影响、花青素在医疗应用中的毒性以及开发新配方在天然色素行业。 ANTHOPLUS 将开发新型植物细胞培养物，用于稳定生产多种花青素。产生这些培养物的新颖程序意味着它们不受现有技术的限制。我们的细胞培养物独一无二，可以持续、高水平地生产多种花青素。增加纯花青素的供应对于着色剂行业来说非常有价值，可用于研究装饰、助色素、pH 对颜色和稳定性的影响，为开发新的植物来源的天然着色剂和新的天然色素配方提供坚实的科学基础。

项目成果

From specialized cell cultures to high quality fine chemicals: ANTHOcyanin production PLatform Using Suspension cultures (ANTHOPLUS)

从专门的细胞培养物到高质量的精细化学品：使用悬浮培养物的花青素生产平台 (ANTHOPLUS)

• 发表时间: 2016
• 期刊: Journal of ISANH Special Issue for Porto Polyphenols 2016, 3 (4)
• 作者: Matros, C

Beyond Purple Tomatoes: Combined Strategies Targeting Anthocyanins to Generate Crimson, Magenta, and Indigo Fruit

• DOI: 10.3390/horticulturae7090327
• 发表时间: 2021-09-01
• 期刊: HORTICULTURAE
• 影响因子: 3.1
• 作者: Butelli, Eugenio;Bulling, Katharina;Martin, Cathie
• 通讯作者: Martin, Cathie

Combined Dietary Anthocyanins, Flavonols, and Stilbenoids Alleviate Inflammatory Bowel Disease Symptoms in Mice.

• DOI: 10.3389/fnut.2017.00075
• 发表时间: 2017
• 期刊: Frontiers in nutrition
• 影响因子: 5
• 作者: Scarano A;Butelli E;De Santis S;Cavalcanti E;Hill L;De Angelis M;Giovinazzo G;Chieppa M;Martin C;Santino A
• 通讯作者: Santino A

Natural Blues: Structure Meets Function in Anthocyanins.

• DOI: 10.3390/plants10040726
• 发表时间: 2021-04-08
• 期刊: Plants (Basel, Switzerland)
• 作者: Houghton A;Appelhagen I;Martin C
• 通讯作者: Martin C