NATURAL PRODUCTS THAT CLEAVE DNA

切割 DNA 的天然产品

• 批准号: 3180063
• 负责人: Sidney Michael Hecht
• 金额: $ 9.54万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3180063
• 关键词: antineoplastics; chelating agents; chemical structure function; drug design /synthesis /production; drug screening /evaluation; nucleic acid structure; plant extracts; tissue /cell culture

Several clinically useful antitumor agents are now recognized to form complexes with one or more metals and to interact with DNA as their metal chelate(s). Further, for most of these agents, DNA interaction (i.e., binding/cleavage) is believed to represent the biochemical locus at which the therapeutic effect is mediated. The objective of this project is the identification of novel natural products that mediate DNA strand scission. Of special interest are agents that do so in a mechanistically novel fashion.

目前已认识到几种临床上有用的抗肿瘤剂 与一种或多种金属形成络合物，并与作为其金属的 DNA 相互作用 螯合物。 此外，对于大多数这些试剂来说，DNA 相互作用（即 结合/切割）被认为代表了生化位点 治疗效果是介导的。 该项目的目标是 介导 DNA 链断裂的新型天然产物的鉴定。 特别令人感兴趣的是在机制新颖的情况下这样做的代理 时尚。