Technical development of a novel vaccine vehicle for cattle pathogens

新型牛病原体疫苗载体的技术开发

• 批准号: BB/L02442X/1
• 负责人: Keith Matthews
• 金额: $ 38.88万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL02442X%2F1
• 关键词: Technical; development; novel; vaccine; vehicle

Trypanosoma theileri is a ubiquitous single celled organism present in cattle herds worldwide. Using knowledge of gene expression and protein trafficking in other trypanosomatid organisms, we have successfully developed T. theileri as a delivery system for vaccine antigens and therapeutics. Following recommendations from several Animal Health companies, we now aim to develop and demonstrate the potential of T. theileri as an effective and practical vaccine-vehicle, providing a clear route to commercialisation.In a two-step development path, Phase 1 will focus on technical refinements and analysis of the viability of the vaccine-vehicle during storage and distribution. The flexibility of the system to express antigens from a range of pathogens will also be established. Phase 2 will entail confirmation of the in vivo efficacy of the refinements developed in Phase 1.Combined the experiments will address key hurdles to the commercial development of this patented vaccine system.

泰勒锥虫是一种普遍存在于全世界牛群中的单细胞生物。利用其他锥虫生物体中基因表达和蛋白质运输的知识，我们成功开发了泰勒锥虫作为疫苗抗原和治疗剂的递送系统。根据多家动物保健公司的建议，我们现在的目标是开发并展示 T. theileri 作为有效且实用的疫苗载体的潜力，为商业化提供明确的途径。在分两步的开发路径中，第一阶段将重点关注对疫苗载体在储存和分发过程中的可行性进行技术改进和分析。还将建立表达一系列病原体抗原的系统的灵活性。第二阶段将确认第一阶段开发的改进的体内功效。综合实验将解决该专利疫苗系统商业开发的关键障碍。

项目成果

An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri.

• DOI: 10.1093/gbe/evx152
• 发表时间: 2017-08-01
• 期刊: Genome biology and evolution
• 影响因子: 3.3
• 作者: Kelly S;Ivens A;Mott GA;O'Neill E;Emms D;Macleod O;Voorheis P;Tyler K;Clark M;Matthews J;Matthews K;Carrington M
• 通讯作者: Carrington M

The genomic basis of host and vector specificity in non-pathogenic trypanosomatids.

• DOI: 10.1242/bio.059237
• 发表时间: 2022-04-15
• 期刊: Biology open
• 影响因子: 2.4