HUMAN PAPILLOMAVIRUSES IN CERVICAL CANCER

宫颈癌中的人乳头瘤病毒

• 批准号: 3182739
• 负责人: JOHN W KREIDER
• 金额: $ 16.05万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3182739
• 关键词: Papillomavirus; athymic mouse; azacitidine; benzopyrenes; cervix neoplasms; chemical carcinogen; cocarcinogen; cutaneous papilloma; diethylstilbestrol; estradiol; herpes simplex virus 2; human papillomavirus; human tissue; neoplasm /cancer transplantation; nitrosamines; nitrosourea; oncogenic virus; radiation carcinogen; viral carcinogenesis; virus DNA; virus antigen; virus related neoplasm /cancer; warts

The participation of human papillomaviruses in the development of cervical cancer is supported by the demonstration in the tumor cells of papillomavirus group-specific antigen and viral particles. In this project we will attempt to induce neoplastic progression of papillomavirus-infected lesions of human cervix by treating the grafts with agents which may represent additional risk factors for the development of cervical cancer. Some of these agents include benzopyrene, n-methylnitrosamine, estrogens, and herpes simplex virus type 2.

人乳头瘤病毒参与宫颈的发展 癌症受到肿瘤细胞中的示威支持 乳头瘤病毒组特异性抗原和病毒颗粒。 在这个项目中 我们将尝试诱导感染乳头瘤病毒的肿瘤进展 通过用剂治疗移植物的剂量，人宫颈病变 代表宫颈癌发展的其他风险因素。 其中一些药物包括苯二吡啶，N-甲基硝基胺，雌激素， 和单纯疱疹病毒2型。

项目成果

Experimental infection with human papillomavirus type 1 of human hand and foot skin.

人手足皮肤1型人乳头瘤病毒实验性感染。

• DOI: 10.1016/0042-6822(90)90503-j
• 发表时间: 1990
• 期刊: Virology
• 影响因子: 3.7
• 作者: Kreider,JW;Patrick,SD;Cladel,NM;Welsh,PA
• 通讯作者: Welsh,PA