Functional Annotation of the Sheep Genome

绵羊基因组的功能注释

• 批准号: BB/L001209/1
• 负责人: David Hume
• 金额: $ 134.66万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL001209%2F1
• 关键词: Functional; Annotation; Sheep; Genome

Animals and humans are made up of many different kinds of organs and cells, each of which requires the actions of a subset of the genes in the genome. We currently know the function of only a subset of the genes in the genome. Much of what we know comes from studies of rodents but their biology is quite different to humans and their small size compromises their use. In the current study we will examine how individual genes are used in every tissue and cell of the sheep. From that information, we will be able to identify sets of genes that are always used together, and infer the function of genes of unknown function from the company they keep. That information will, in turn, allow us to interpret studies of the genetics and genomics of large animals, including humans (this study could not be done on a human). This will, in turn, inform the rational breeding of livestock for improved performance and welfare through selection for disease resistance. It will also give us a better understanding of the basic biology of humans that can be translated in better lifelong health.

动物和人类由许多不同种类的器官和细胞组成，每种器官和细胞都需要基因组中基因子集的作用。我们目前仅知道基因组中基因的一个子集的功能。我们所知道的大部分来自对啮齿动物的研究，但它们的生物学与人类完全不同，它们的小体积损害了它们的使用。在当前的研究中，我们将研究如何在绵羊的每个组织和细胞中使用单个基因。从这些信息中，我们将能够确定始终一起使用的基因集，并从其保留的公司中推断出未知功能的基因的功能。反过来，这些信息将使我们能够解释包括人类在内的大型动物的遗传学和基因组学的研究（这项研究不能在人类上进行）。反过来，这将为牲畜的合理育种提供信息，从而通过选择抗病性来提高绩效和福利。这也将使我们对可以在更好的终身健康中翻译的人类的基本生物学有更好的了解。

项目成果

Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression

反刍动物从出生到成年胃肠道的全面转录谱揭示了强烈的发育阶段特异性基因表达

• DOI: 10.1101/364752
• 发表时间: 2018
• 作者: Bush S

Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries.

• DOI: 10.1186/s12859-017-1714-9
• 发表时间: 2017-06-13
• 期刊: BMC bioinformatics
• 影响因子: 3
• 作者: Bush SJ;McCulloch MEB;Summers KM;Hume DA;Clark EL
• 通讯作者: Clark EL

The genomic architecture of mastitis resistance in dairy sheep.

• DOI: 10.1186/s12864-017-3982-1
• 发表时间: 2017-08-16
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Banos G;Bramis G;Bush SJ;Clark EL;McCulloch MEB;Smith J;Schulze G;Arsenos G;Hume DA;Psifidi A
• 通讯作者: Psifidi A

Genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep

基因组分析支持奶羊产奶量和乳腺炎抵抗力同步遗传改良的可行性

• DOI: 10.1101/577015
• 发表时间: 2019
• 作者: Banos G

A high resolution atlas of gene expression in the domestic sheep (Ovis aries).

• DOI: 10.1371/journal.pgen.1006997
• 发表时间: 2017-09
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Clark EL;Bush SJ;McCulloch MEB;Farquhar IL;Young R;Lefevre L;Pridans C;Tsang HG;Wu C;Afrasiabi C;Watson M;Whitelaw CB;Freeman TC;Summers KM;Archibald AL;Hume DA
• 通讯作者: Hume DA