INTERCELLULAR COMMUNICATION AND CANCER

细胞间通讯与癌症

• 批准号: 3163933
• 负责人: WERNER R LOEWENSTEIN
• 金额: $ 31.03万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-04-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3163933
• 关键词: cell growth regulation; cell type; cellular oncology; cyclic AMP; electrical measurement; electron microscopy; electrophysiology; fluorescent dye /probe; freeze etching; hypercalcemia; intercellular connection; membrane permeability; neoplasm /cancer diagnosis; neoplasm /cancer genetics; neoplastic cell; neoplastic growth; temperature sensitive mutant; tissue /cell culture; viral carcinogenesis

This is an investigation of the role of (junctional) cell-to-cell communication in cancer growth and the role of communication defects in the etiology of cancerous growth. Sensitive fluorescent tracer techniques were developed for detecting deviations of normal communication. Such deviations were found in various Rous sarcoma-transformed cell types and were shown to be independent of cytoskeletal alterations caused by the virus. A control of communication by hormones (catecholamines and prostaglandins) was found. (A)

这是对（连接）细胞到细胞的作用的研究 癌症增长中的交流以及沟通缺陷在 癌变的病因。 敏感的荧光示踪技术是 开发用于检测正常交流的偏差。 这样的 在各种ROUS肉瘤转化的细胞类型中发现了偏差， 被证明与由由细胞骨架的改变无关 病毒。 荷尔蒙（儿茶酚胺和 发现前列腺素）。 （一个）