POTENTIAL TUMOR OR ORGAN IMAGING AGENTS

潜在的肿瘤或器官成像剂

• 批准号: 3163309
• 负责人: RAYMOND E COUNSELL
• 金额: $ 17.17万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 1987-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3163309
• 关键词: adrenal medulla; adrenal neoplasm; aminoacridines; androgens; antiarrhythmic agent; autoradiography; brain neoplasms; breast neoplasms; chemical synthesis; contrast media; drug metabolism; estrogens; female reproductive system neoplasm; image enhancement; image processing; imaging /visualization /scanning; male reproductive system neoplasm; myocardium disorder; neoplasm /cancer radionuclide diagnosis; pancreas neoplasms; parathyroid neoplasms; pineal body neoplasm; pituitary neoplasms; polyamines; radionuclide imaging /scanning; radiopharmacology; radiotracer; steroid hormone; tomography

The goals of this project have been to design, synthesize and evaluate new compounds as potential organ or tumor-imaging agents. Pharmacological and biochemical principles have served as the basis for achieving site-specific delivery of these agents. Current research is focused on the synthesis of radioiodinated and polyiodinated analogs of naturally-occurring lipids as potential scintigraphic agents and radiopaques, respectively. Of special interest are iodinated analogs of sterol esters, triglycerides and phospholipids. The target compounds will be designed so as to provide information not only on the ability of these agents to accumulate in specific tissues but also on their capacity to participate in biochemical transformations peculiar to such tissues. Accordingly, such probes offer the potential of furnishing a noninvasive means for ascertaining both organ structure and function. All new agents will be labeled with iodine-125 for initial biodistribution studies in normal rats. Promising agents will then be followed up by gamma-camera scintigraphy and computed tomography in the appropriate rat or rabbit model. Selected agents will also be incorporated into lipoproteins and liposomes in order to capitalize on the known biodistribution properties of these macromolecular complexes. Such research holds significant promise for the eventual development of new radiologic agents for the diagnosis of various hepatic, endocrine, and cardiovascular disorders.

该项目的目标是设计，合成和评估新 作为潜在器官或肿瘤成像剂的化合物。 药理和 生化原则已成​​为实现特定地点的基础 这些代理的交付。 当前的研究集中于合成 自然脂质脂质的放射性固化和多层类似物作为 潜在的闪烁显像剂和射射道。 特别 兴趣是固醇酯，甘油三酸酯和 磷脂。 目标化合物将设计为 不仅有关这些代理人积累的能力的信息 特定的组织，但也以其参与生化的能力 这种组织特有的转化。 因此，此类探针提供了 提供无创手段来确定两个器官的潜力 结构和功能。 所有新代理商都将用碘标记为125 正常大鼠的初始生物分布研究。 有希望的代理人将 随后是伽玛相机闪光灯和计算机断层扫描 适当的大鼠或兔模型。 选定的代理也将合并 进入脂蛋白和脂质体，以利用已知的 这些大分子复合物的生物分布特性。 这样的 研究对最终发展具有巨大的希望 用于诊断各种肝，内分泌和 心血管疾病。