POTENTIAL TUMOR OR ORGAN IMAGING AGENTS

潜在的肿瘤或器官成像剂

基本信息

批准号：
3163304
负责人：
RAYMOND E COUNSELL
金额：
$ 23.09万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
起止时间：
1979-05-01 至 1990-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3163304
关键词：
adrenal medulla adrenal neoplasm aminoacridines androgens antiarrhythmic agent autoradiography brain neoplasms breast neoplasms chemical synthesis contrast media drug metabolism estrogens female reproductive system neoplasm image enhancement image processing imaging /visualization /scanning male reproductive system neoplasm myocardium disorder neoplasm /cancer radionuclide diagnosis pancreas neoplasms parathyroid neoplasms pineal body neoplasm pituitary neoplasms polyamines radionuclide imaging /scanning radiopharmacology radiotracer steroid hormone tomography tritium

adrenal medulla adrenal neoplasm aminoacridines androgens antiarrhythmic agent autoradiography brain neoplasms breast neoplasms chemical synthesis contrast media drug metabolism estrogens female reproductive system neoplasm image enhancement image processing imaging /visualization /scanning male reproductive system neoplasm myocardium disorder neoplasm /cancer radionuclide diagnosis pancreas neoplasms parathyroid neoplasms pineal body neoplasm pituitary neoplasms polyamines radionuclide imaging /scanning radiopharmacology radiotracer steroid hormone tomography tritium

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项目摘要

The goals of this project have been to design, synthesize and evaluate new compounds as potential organ- or tumor-imaging agents. Pharmacological and biochemical principles have served as the basis for achieving site-specific delivery of these agents. Current research is focused on the synthesis of radioiodinated and polyiodinated analogs of naturally-occurring lipids as potential scintigraphic agents and radiopaques, respectively. Of especial interest are iodinated analogs of fatty acids, acylcarnitines, sterol esters, diacyglycerides, triglycerides, phospholipid ethers, and phospholipids. The target compounds will be designed so as to provide information not only on the ability of these agents to accumulate in specific tissues but also on their capacity to participate in biochemical transformations peculiar to such tissues. Accordingly, such probes offer the potential of furnishing a noninvasive means for ascertaining both organ structure and function. All new agents will be labeled with iodine-125 for initial biodistribution studies in normal rats. Promising agents will then be followed up by Gamma-camera scintigraphy and computed tomography in the appropriate rat or rabbit model. Selected agents will also be incorporated into natural or reconstituted lipoproteins in order to capitalize on the known biodistribution properties of these macromolecular vesicles. Such research holds significant promise for the eventual development of new radiologic agents for the diagnosis of various hepatic, endocrine, and cardiovascular disorders.

该项目的目标是设计，合成和评估新化合物作为潜在的器官或肿瘤成像剂。药理和生化原则已成为实现特定地点的基础这些代理的交付。当前的研究集中于合成自然脂质脂质的放射性固化和多层类似物作为潜在的闪烁显像剂和射射道。特别是感兴趣的是脂肪酸，酰基肉碱，固醇的碘化类似物酯，二甘油三酸酯，甘油三酸酯，磷脂醚和磷脂。目标化合物将设计为不仅有关这些代理人积累的能力的信息特定的组织，但也以其参与生化的能力这种组织特有的转化。因此，此类探针提供了提供无创手段来确定两个器官的潜力结构和功能。所有新代理商都将用碘标记为125 正常大鼠的初始生物分布研究。有希望的代理人将随后是伽玛相机闪光灯和计算机断层扫描适当的大鼠或兔模型。选定的代理也将合并进入天然或重构的脂蛋白，以利用这些大分子囊泡的已知生物分布特性。这样的研究对最终发展具有巨大的希望用于诊断各种肝，内分泌和心血管疾病。