BACTERIAL VAGINOSIS--PATHOGENESIS AND IMPACT ON SEXUALLY TRANSMITTED DISEASES

细菌性阴道病——发病机制及其对性传播疾病的影响

• 批准号: 6099951
• 负责人: JANE R SCHWEBKE
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6099951
• 关键词: Lactobacillus; Mycoplasma; Mycoplasmatales; bacterial disease; cervical /vaginal smear; communicable disease transmission; disease /disorder proneness /risk; endometrium; female; human subject; nucleic acid hybridization; pathologic process; peroxides; polymerase chain reaction; relapse /recurrence; sexually transmitted diseases; southern blotting; vaginitis

Bacterial vaginosis (BV) is the most prevalent cause of symptomatic vaginal discharge in women. Its etiology is unknown, however it is characterized by displacement of the normal vaginal flora with large numbers of anaerobic and facultatively anaerobic bacteria Epidemiologic associations exist between BV and sexually transmitted diseases (STDs) of the lower and upper female genital tract, however cause and effect are not known. The specific aims of this proposal are to determine the impact of BV on the acquisition of sexually transmitted female genital tract infections and to clarify the pathogenesis of BV. The role of Mycoplasma genitalium as well as newly described biotypes of Ureaplasma urealyticum in BV will be explored. A large cohort of women at high-risk for BV and STDs will be followed prospectively for 6 months. Extensive behavioral and clinical data collected during these visits as well as home diaries and self-obtained home vaginal smears will be used to create a time-line of events. Additionally, independently obtained behavioral data from the male partners will be available from Project #1 (Etiology of Nongonococcal Urethritis) in this STD CRC proposal. If the hypothesis advanced is correct, i.e. the presence of BV facilitates acquisition of STDs and if the pathogenesis of BV can be further clarified, then primary prevention of BV could substantially impact STD control. This project will interact significantly with Projects 1 and 4 of this proposal with overlap of study populations, behavioral data, and clinical specimens.

细菌性阴道病（BV）是引起症状的最常见原因 女性的阴道分泌物。 其病因不明，但 其特点是正常阴道菌群发生大量移位 厌氧和兼性厌氧细菌的数量 流行病学 BV 与性传播疾病 (STD) 之间存在关联 女性下生殖道和上生殖道，但因果关系并不相同 已知。该提案的具体目标是确定 BV 对获得性传播女性生殖道的影响 感染并阐明 BV 的发病机制。支原体的作用 生殖器以及新描述的解脲支原体生物型 将在 BV 进行探索。一大群女性患有 BV 和 STD 将前瞻性跟踪 6 个月。广泛的行为和 在这些访问期间收集的临床数据以及家庭日记和 自制的家庭阴道涂片将用于创建一个时间线 事件。此外，还独立获得了男性的行为数据 合作伙伴将从项目#1（非淋菌病的病因学）中获得 性病 CRC 提案中的尿道炎）。如果提出的假设是 正确，即 BV 的存在促进了 STD 的感染，并且如果 BV发病机制可进一步明确，一级预防 BV 可能会严重影响 STD 控制。 该项目将与本项目的项目 1 和 4 产生显着的交互作用 研究人群、行为数据和临床重叠的提案 标本。