Engineering the trafficking of nanoparticles within cells

设计纳米颗粒在细胞内的运输

• 批准号: DP180100844
• 负责人: A/Prof Georgina Such
• 金额: $ 30.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100844
• 关键词: Engineering; trafficking; nanoparticles; within; cells

This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable polymers.

该项目旨在设计能够在细胞内有效运输的响应式纳米颗粒。释放热货物的部位对于提高许多处理效率（例如疫苗输送）至关重要。因此，必须对纳米颗粒结构进行设计以控制细胞行为的基本了解。该项目将设计新的聚合物纳米材料，并研究其结构对生物学特性的影响。该项目的好处将包括用于改善纳米颗粒设计的新基本见解，以及在可生物降解聚合物领域扩展澳大利亚知识库。