Unravelling Efficient Nucleic Acid Delivery Using Multilayer Nanoparticles

使用多层纳米粒子揭示有效的核酸输送

• 批准号: DP240102642
• 负责人: A/Prof Georgina Such
• 金额: $ 39.18万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102642
• 关键词: Unravelling; Efficient; Nucleic; Acid; Delivery

Developing smarter nanoparticles is critical for maximising the potential of biological therapeutics such as nucleic acids. Currently, the efficiency of nanoparticle delivery remains low due to the inability of carriers to migrate different biological regions. The aim of this project is to develop responsive polymer nanoparticles that can more effectively migrate cell barriers by a two-staged release based on the combination of different self-immolative polymers. This project will allow the development of design rules for understanding how nanoparticle structure can be optimised to improve nucleic acid delivery. This work will have important benefits such as developing new nanotechnology industry and skilled graduates for Australia.

开发更明智的纳米颗粒对于最大程度地提高生物学疗法（例如核酸）的潜力至关重要。目前，由于载体无法迁移不同的生物区域，纳米颗粒递送的效率仍然很低。该项目的目的是开发响应式聚合物纳米颗粒，这些纳米颗粒可以通过基于不同自耐聚合物的组合的两级释放来更有效地迁移细胞屏障。该项目将允许制定设计规则，以了解如何优化纳米颗粒结构以改善核酸的递送。这项工作将具有重要的好处，例如开发新的纳米技术行业以及澳大利亚熟练的毕业生。