PEPTIDE PROCESSING ENZYMES IN THE PLACENTA

胎盘中的肽加工酶

• 批准号: 2561858
• 负责人: Sandra Eve Reznik
• 金额: $ 8.52万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2561858
• 关键词: carboxypeptidase; cell cell interaction; endothelin; enzyme activity; enzyme mechanism; human tissue; immunocytochemistry; in situ hybridization; laboratory rat; metalloendopeptidases; peptides; placenta; pregnancy; transfection

DESCRIPTION (Adapted from applicant's description): This K08 award will allow the candidate to obtain the scientific expertise and to conduct studies that will advance understanding of the functions of selected placental peptidases. Specifically, she will test hypotheses about the mechanisms by which alterations in the enzymes that process and metabolize Endothelin-1 are related to the pathogenesis of pre-eclampsia and pre-term labor and by which alterations in the carboxypeptidases that process a variety of peptide hormones and growth restriction. Specific aim 1 will test the hypothesis that two closely related metalloendopeptidases, endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase (NEP), function in the regulation of levels of endothelin-1 (ET-1) in the placenta and that ET-1 functions as a common pathway in the pathogenesis of pre-eclampsia and pre-term labor. Aim 2 will test the hypothesis that recently identified members of the carboxypeptidase E family, highly concentrated in the rat placenta, also function as peptide processing enzymes in the human placenta. Specific aim 3 will test the hypothesis that the novel placental proteins also have nonenzymatic functions.

描述（根据申请人的描述改编）：该 K08 奖项将 让候选人获得科学专业知识并进行 研究将促进对所选功能的理解 胎盘肽酶。 具体来说，她将测试有关的假设 处理和代谢酶发生变化的机制 Endothelin-1与先兆子痫和早产的发病机制有关 劳动和处理羧肽酶的改变 多种肽激素和生长限制。 具体目标1将 检验两种密切相关的金属内肽酶的假设， 内皮素转换酶-1 (ECE-1) 和中性内肽酶 (NEP)， 调节胎盘内皮素-1 (ET-1) 水平的功能 ET-1 在疾病发病机制中发挥着共同途径的作用 先兆子痫和早产。 目标 2 将检验以下假设： 最近鉴定出羧肽酶 E 家族的成员，高度 集中在大鼠胎盘中，也具有肽加工作用 人类胎盘中的酶。 具体目标 3 将检验以下假设： 新型胎盘蛋白还具有非酶功能。