AFRICAN AMERICAN STUDY OF KIDNEY DISEASE

非裔美国人的肾脏疾病研究

• 批准号: 2734187
• 负责人: JACQUES J BOURGOIGNIE
• 金额: $ 38.46万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2734187
• 关键词: African American; antihypertensive agents; blood pressure; cardiovascular disorder chemotherapy; chronic renal failure; clinical trials; cooperative study; glomerular filtration rate; human subject; human therapy evaluation; hypertension; nephrosclerosis

The University of Miami proposes to participate as a clinical center in the African American Study of Kidney Disease (AASK) to compare the efficacy of double-masked administration of randomized antihypertensive drugs on blood pressure control and progressive renal disease. A team of physicians and paramedical personnel, most of whom were involved in the NIH sponsored Modification of Diet in Renal Disease Study and experienced in the longterm care of patients with hypertension and renal disease, is committed to an effective conduct of the Study. An administrative center within the Division of Nephrology and an outpatient clinic center will be dedicated to the AASK Miami team. The Clinical Research Center will be used for patients requiring hospitalization. Laboratory, pharmacy and radiopharmacy support will be provided by the University of Miami Hospital and Clinics. Potentially eligible African-American men and women can be identified on- campus from the Renal and Hypertension, General Medicine, and family Medicine Clinics at the University of Miami/Jackson Memorial Medical Center, and the Renal and Hypertension Clinics at the Miami Veterans Administration Medical Center, and the Clinics of UM Care and Jackson Memorial Medical Center Health Plans. Enrollment of patients will also be sought off-campus from nephrologists in practice, the Association of Black Cardiologists, the Dade County Medical Association, local HMO's, family medicine practice groups, and directly, through local advertisement within the African-American community through newspapers, radio, television, churches, social organizations, and the Dade County School District. The population available and the interest in the Study by patients and physicians alike indicate that 65 selected volunteer patients with hypertension and chronic renal disease from arteriolar nephrosclerosis can be entered, randomized and followed in Miami. The Miami team is committed to accept and implement the common protocol and procedures approved by the Steering Committee and NIDDK staff.

迈阿密大学提议作为临床中心参与 非裔美国人肾脏病研究 (AASK) 比较 随机抗高血压双盲给药的疗效 控制血压和进行性肾病的药物。 由医生和护理人员组成的团队，其中大多数人都参与其中 在 NIH 资助的肾病饮食调整研究中 对高血压、肾病患者的长期护理有丰富的经验 疾病，致力于有效地进行研究。 一个 肾内科行政中心和门诊部 诊所中心将专门为 AASK 迈阿密团队服务。 临床 研究中心将用于需要住院治疗的患者。 实验室、药房和放射性药物支持将由 迈阿密大学医院和诊所。 可以通过以下方式确定潜在合格的非裔美国男性和女性： 肾脏与高血压、普通医学和家庭校园 迈阿密大学/杰克逊纪念医疗中心的医学诊所 中心以及迈阿密退伍军人中心的肾脏和高血压诊所 行政医疗中心、UM Care 诊所和 Jackson 诊所 纪念医疗中心健康计划。 患者的登记也将 在实践中向校外肾脏病专家寻求帮助，黑人协会 心脏病专家、戴德县医学协会、当地 HMO、家庭 医学实践团体，并直接通过当地的广告 通过报纸、广播、电视、 教堂、社会组织和戴德县学区。 这 可用人群以及患者对研究的兴趣和 医生们都表示，65 名选定的自愿患者患有 高血压和小动脉性肾硬化引起的慢性肾病可 被输入、随机并在迈阿密进行跟踪。 迈阿密团队致力于 接受并执行经国家批准的共同协议和程序 指导委员会和 NIDDK 工作人员。