REGULATION AND FUNCTION OF SALIVATION IN VECTORS

媒介唾液分泌的调节和功能

• 批准号: 3128107
• 负责人: JOSE M.C. RIBEIRO
• 金额: $ 11.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-30 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3128107
• 关键词: Culicidae; arthropod nonpollutant control; chromatography; communicable disease control; electron microscopy; genetic strain; growth media; hamsters; host organism interaction; immunochemistry; laboratory mouse; laboratory rabbit; leukotrienes; microorganism culture; microorganism growth; prostacyclins; saliva; salivation; ticks; vole

Ultimately, we seek to understand how saliva of arthropods contributes to the interaction of vectors with vertebrate hosts, both in regulating the quantity of secretion delivered to the host and in modifying the physiological response of the host to the bite lesion. Toward this end, we shall investigate the (1) events leading toward salivation, (2) pharmacological properties of saliva and (3) the role of saliva in blood finding and blood feeding. Mosquitoes and ixodid ticks will provide our main subjects for study; but, other arthropods, including sandflies, blackflies and fleas, will be included in certain studies. In particular, studies on mechanisms regulating salivation in mosquitoes will: (a) determine salivary levels of mosquito apyrase in different feeding modes, (b) describe the action of agonists inducing mosquito salivation and (c) define the innervation of the salivary glands. Pharmacological studies will investigate: (a) properties of the saliva of blackflies and fleas; (b) the mode of action of the erythema inducing factor (EIS) of Lutzomyia longipapis, (c) the presence of prostacyclin and leukotrienes in the saliva of a tick and (d) the mode of action of an anti-complement activity of tick saliva. Studies on the role of saliva in feeding will examine the tolerance or resistance of different hosts to repeated ixodid tick infestations and the role of saliva in such processes. This work explores the suggestion that saliva of hematophagous arthropods mainly serves an antihemostatic and antiinflammatory role during blood-finding and blood-feeding.

最终，我们试图了解节肢动物的唾液如何贡献 向量与脊椎动物宿主的相互作用都在调节 分泌的数量交付给主机并修改 宿主对咬合病变的生理反应。 为此，我们 应研究导致唾液的（1）事件，（2） 唾液的药理特性和（3）唾液在血液中的作用 发现和献血。 蚊子和ixodid tick将提供我们的 主要学科；但是，其他节肢动物，包括沙氟， 黑鳍和跳蚤将包括在某些研究中。 特别是，关于调节蚊子唾液的机制的研究 威尔：（a）确定不同的蚊子中的唾液水平 进食模式，（b）描述诱导蚊子的激动剂的作用 唾液和（c）定义唾液腺的神经。 药理学研究将研究：（a） 黑鳍和跳蚤； （b）诱导红斑的作用方式 lutzomyia longipapis的因子（EIS），（c）前列环蛋白和 tick唾液中的白细胞和（d） tick唾液的抗汇合活性。 研究唾液在 喂养将检查不同宿主对 重复的ixodid tick侵犯和唾液在此类过程中的作用。 这项工作探讨了造血节肢动物唾液的建议 在 调查和喂血。