REGULATION AND FUNCTION OF SALIVATION IN VECTORS

媒介唾液分泌的调节和功能

• 批准号: 2060752
• 负责人: JOSE M.C. RIBEIRO
• 金额: $ 21.87万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-30 至 1996-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2060752
• 关键词: Culicidae; Psychodidae; Siphonaptera; antiinflammatory agents; arthropod borne communicable disease; chemical structure function; communicable disease transmission; eating; electron microscopy; enzyme linked immunosorbent assay; enzyme mechanism; erythema; hemostasis; high performance liquid chromatography; host organism interaction; immunosuppression; neutrophil; pharmacology; platelet activation; saliva; salivation; ticks; vasoactive agent

Ultimately, we seek to understand how saliva of arthropods contribute to the interaction of vectors with vertebrate hosts. Toward this end, we shall investigate anti-hemostatic, vasoactive anti-inflammatory, and immunosuppressive properties of vector saliva, characterizing them both pharmacologically and biochemically. Ixodid and argasid ticks, sand flies, triatomine bugs, and fleas will be included in these studies. In particular, anti-hemostatic studies will concentrate on the antiplatelet activity of Ornithodorus moubata. Vasoactive studies will study further the erythema-inducing factor of Lutzomyia longipalpis, characterize the salivary vasodilator of Rhodnius prolixus, and investigate the erythema-inducing factor of Xenopsylla cheopis. Anti-inflammatory activities will investigate the kininase activity of O. moubata and characterize the LTB immunoreactive material of Ixodes dammini, possibly an LTB antagonist. Immunosuppressive activities will concentrate on the anti-neutrophil activity of I. dammini saliva, as well as its anti-lymphocyte activation property. This work explores the suggestion that saliva of hermatophagous arthropods mainly serves an antihemostatic and antiinflammatory role during blood-finding and blood-feeding. As this idea is further explored, it is our hope more will be learned on the biology of vectors and the parasites they vector, and that novel pharmacological compounds will be found.

最终，我们试图了解节肢动物的唾液如何贡献 向量与脊椎动物宿主的相互作用。为此，我们将 研究抗震荡，血管活性抗炎和 向量唾液的免疫抑制特性，表征它们 在药理和生化上。 ixodid and argasid tick虫，沙蝇， 这些研究中将包括三位生胺错误和跳蚤。 特别是，抗震荡研究将集中于抗血小板上 Ornithodorus Moubata的活动。血管活性研究将进一步研究 lutzomyia longipalpis的红斑诱导因子，表征 罗德尼乌斯·普拉里克斯（Rhodnius Prolixus）的唾液血管扩张剂，并研究 Xenopsylla Cheopis的红斑诱导因子。消炎（药 活动将调查O. Moubata和 表征ixodes dammini的LTB免疫反应性材料，可能 LTB拮抗剂。免疫抑制活动将集中于 I. Dammini唾液及其抗营养性活性及其 抗淋巴细胞激活特性。 这项工作探讨了咽喉节肢动物的唾液的建议 在 调查和喂血。随着这个想法的进一步探讨，它是 我们的希望将在媒介和寄生虫的生物学上学习更多 它们的载体，并发现新型的药理学化合物。

项目成果

The salivary catechol oxidase/peroxidase activities of the mosquito Anopheles albimanus.

白按蚊唾液儿茶酚氧化酶/过氧化物酶活性。

• DOI: 10.1242/jeb.179.1.273
• 发表时间: 1993
• 期刊: The Journal of experimental biology
• 作者: Ribeiro,JM;Nussenzveig,RH
• 通讯作者: Nussenzveig,RH

Biochemical insights derived from insect diversity.

来自昆虫多样性的生化见解。

• DOI: 10.1146/annurev.bi.61.070192.000511
• 发表时间: 1992
• 期刊: Annual review of biochemistry
• 影响因子: 16.6
• 作者: Law,JH;Ribeiro,JM;Wells,MA
• 通讯作者: Wells,MA

Anti-tick antibodies: an epidemiologic tool in Lyme disease research.

抗蜱抗体：莱姆病研究中的流行病学工具。

• DOI: 10.1093/oxfordjournals.aje.a115643
• 发表时间: 1990
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Schwartz,BS;Ribeiro,JM;Goldstein,MD
• 通讯作者: Goldstein,MD

Nitric oxide loading of the salivary nitric-oxide-carrying hemoproteins (nitrophorins) in the blood-sucking bug Rhodnius prolixus.

吸血虫 Rhodnius prolixus 唾液中携带一氧化氮的血红蛋白（硝基蛋白）的一氧化氮负荷。

• DOI: 10.1242/jeb.198.5.1093
• 发表时间: 1995
• 期刊: The Journal of experimental biology
• 作者: Nussenzveig,RH;Bentley,DL;Ribeiro,JM
• 通讯作者: Ribeiro,JM

Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.

• DOI: 10.1084/jem.161.2.332
• 发表时间: 1985-02-01
• 期刊: The Journal of experimental medicine
• 作者: Ribeiro JM;Makoul GT;Levine J;Robinson DR;Spielman A
• 通讯作者: Spielman A