Modelling systems for managing bee disease: the epidemiology of European Foulbrood

管理蜜蜂疾病的建模系统：欧洲腐臭病的流行病学

• 批准号: BB/I000801/1
• 负责人: Giles Budge
• 金额: $ 35.55万
• 依托单位: Fera Science (United Kingdom)
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI000801%2F1
• 关键词: Modelling; systems; managing; bee; disease

This project will provide a step-change in our understanding of managed pollinator disease. We will use a combined modelling and molecular approach to investigate the dynamics of European Foul Brood (EFB) as an exemplar of endemic brood disease of honey bee colonies using historic data derived from long-term monitoring of apiaries in England and Wales. We will utilise a program of statistical, analytical and spatially explicit modelling to address the problem. Statistical modelling approaches will be used to identify putative covariates involved in the epidemiology of disease (e.g. land use, weather, management practices) (Newcastle); analytical modelling approaches will be used to investigate the role of transmission processes in determining the epidemiology of disease (Warwick & Bath); and spatially explicit models to investigate spatial spread of disease in the context of investigating the efficacy of different practical control measures (Warwick & Newcastle). The modelling will be parameterised using historic datasets which include the timing and reported incidence of EFB distribution in honey bee apiaries across England and Wales (Fera). Molecular approaches based on microsatellite markers and comparative genomics will be employed to characterise host and parasite diversity (Fera & Bath) for use as additional covariates in the statistical, analytical and spatially explicit models exploring the epidemiology of EFB in relation to host resistance. These data will be used for the testing and validation of the theoretical and spatially explicit models. We (Fera & Bath) have, in collaboration with the Sanger centre in Cambridge, already generated a draft genome sequence for M. plutonius. These data will greatly facilitate the identification of suitable markers for the characterisation of large and representative population samples and will also shed light on the genes responsible for virulence, and how pathogenesis proceeds in the bee host. EFB will provide a paradigm which we can test against other pollinator diseases. For example, developed models will be used to investigate the epidemiology of 14 honey bee diseases collected across 5000 apiaries as part of an ongoing Defra funded monitoring programme (Fera). Dissemination of project results is explicit within the project framework and includes, the production of a list of key end-users, stakeholder workshops, bi-annual project newsletters, reporting in industry literature, a disease management summary document and conference attendance. The modelling analytical and spatially explicit models developed within this project will act as tools to guide strategy in the face of a plethora of disease threats for managed and wild pollinators.

该项目将在我们对托管传粉媒介疾病的理解中提供逐步变化。我们将使用一种组合的建模和分子方法来研究欧洲犯规的育雏（EFB）的动力学，作为蜂蜜蜜蜂菌落中流行的育雏疾病的一个典范，使用了对英格兰和威尔士的养蜂场的长期监测得出的历史数据。我们将利用一个统计，分析和空间显式建模的程序来解决该问题。统计建模方法将用于确定参与疾病流行病学的推定协变量（例如土地使用，天气，管理实践）（纽卡斯尔）；分析建模方法将用于研究传播过程在确定疾病流行病学（Warwick＆Bath）中的作用；以及在研究不同实践控制措施（Warwick＆Newcastle）的功效的背景下，在空间上研究疾病的空间扩散。该建模将使用历史数据集进行参数化，其中包括英格兰和威尔士（FERA）的Honey Bee Apiaries中EFB分布的时间和报告的发生率。将采用基于微卫星标记的分子方法和比较基因组学来表征宿主和寄生虫多样性（FERA＆BATH），以用作统计，分析和空间显式模型的其他协变量，以探索EFB与宿主抗性有关的EFB流行病学。这些数据将用于理论和空间显式模型的测试和验证。我们（Fera＆Bath）与剑桥的Sanger中心合作，已经为M. Plutonius生成了基因组序列草案。这些数据将大大促进合适的标记物来表征大型和代表性种群样本，还将阐明负责毒力的基因，以及在蜜蜂宿主中如何进行发病机理。 EFB将提供一个范式，我们可以针对其他传粉媒介疾病进行测试。例如，开发的模型将用于研究正在进行的Defra资助的监测计划（FERA）的一部分，在5000个养蜂场中收集的14种蜜蜂疾病的流行病学。项目结果的传播在项目框架内是明确的，包括关键最终用户，利益相关者研讨会，两年一次的项目新闻通讯，行业文献报道，疾病管理摘要文件和会议出勤的列表。面对托管和野生传粉媒介的疾病威胁，该项目中开发的模型分析和空间显式模型将充当指导战略的工具。

项目成果

Evidence for pollinator cost and farming benefits of neonicotinoid seed coatings on oilseed rape.

• DOI: 10.1038/srep12574
• 发表时间: 2015-08-13
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Budge GE;Garthwaite D;Crowe A;Boatman ND;Delaplane KS;Brown MA;Thygesen HH;Pietravalle S
• 通讯作者: Pietravalle S

Supplementary Material from Efficient use of sentinel sites: detection of invasive honeybee pests and diseases in the UK

有效利用哨点的补充材料：英国入侵蜜蜂病虫害的检测

• DOI: 10.6084/m9.figshare.4872911
• 发表时间: 2017
• 作者: Keeling M

Standard methods for European foulbrood research

• DOI: 10.3896/ibra.1.52.1.12
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF APICULTURAL RESEARCH
• 影响因子: 1.9
• 作者: Forsgren, Eva;Budge, Giles E.;Hornitzky, Michael A. Z.
• 通讯作者: Hornitzky, Michael A. Z.

Predicting the spread of the Asian hornet (Vespa velutina) following its incursion into Great Britain.

• DOI: 10.1038/s41598-017-06212-0
• 发表时间: 2017-07-24
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Keeling MJ;Franklin DN;Datta S;Brown MA;Budge GE
• 通讯作者: Budge GE

Population genetic diversity and dynamics of the honey bee brood pathogen Melissococcus plutonius in a region with high prevalence.

• DOI: 10.1016/j.jip.2022.107867
• 发表时间: 2023-02
• 期刊: JOURNAL OF INVERTEBRATE PATHOLOGY
• 影响因子: 3.4
• 作者: Grossar, Daniela;Haynes, Edward;Budge, Giles E.;Parejo, Melanie;Gauthier, Laurent;Charriere, Jean-Daniel;Chapuisat, Michel;Dietemann, Vincent
• 通讯作者: Dietemann, Vincent