PHYSIOLOGICAL STUDIES ON A PARASITIC NEMATODE

寄生线虫的生理学研究

• 批准号: 3126167
• 负责人: ANTONY O. STRETTON
• 金额: $ 14.54万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3126167
• 关键词: biological models; choline acetyltransferase; electrophysiology; gamma aminobutyrate; interneurons; larva; motor neurons; muscle pharmacology; neuromuscular function; neurons; neurophysiology; neurotransmitters; synapses

The aim of the project is to understand the way the movement of a parasitic nematode is controlled. For the control of nematodes, which are important human parasites, a detailed knowledge of their fundamental physiological mechanisms will enable new drugs to be designed. We propose to study the motor nervous system of Ascaris in order to understand how the output signals to muscles are generated and coordinated to produce locomotion. We will use anatomical, pharmacological and physiological techniques to achieve this. To increase the spectrum of drugs available to paralyze nematodes we will also attempt to identify compounds that selectively inhibit different classes of nerve cells in the system.

该项目的目的是了解寄生的运动方式 线虫受到控制。 为了控制线虫，这很重要 人类寄生虫，对其基本生理学的详细知识 机制将使新药能够设计。 我们建议研究 Ascaris的运动神经系统，以了解输出如何 产生并协调肌肉的信号以产生运动。 我们 将使用解剖学，药理和生理技术来 实现这一目标。 增加可用于瘫痪的药物的光谱 线虫我们还将尝试识别有选择性的化合物 抑制系统中不同类别的神经细胞。