MENOPAUSE, AGING, & OSTEOPOROSIS--CROSS-CULTURAL INQUIRY

更年期、衰老、

• 批准号: 3118785
• 负责人: YEWOUBDAR BEYENE
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3118785
• 关键词: Native Americans; aging; body physical activity; bone fracture; diet; dietary calcium; disease /disorder proneness /risk; epidemiology; female; human subject; lifestyle; medical records; menopause; osteoporosis; postmenopause; reproductive hormone; rural area; urban area

Cross-cultural studies of age and menopause related skeletal changes are absent and detailed research addressing this issue will contribute new insight into the study of menopause, aging, and osteoporosis. The aim of this proposed cross-cultural study upon is to provide comparative data on the patterns of age-related skeletal and hormonal status in women in a culture which is unlike Western industrialized societies. The culture selected for the study is rural Mayan women in southeastern Yucatan, Mexico. Data from preliminary research indicate that, unlike women in industrialized Western societies, most Mayan women marry early in their teens. Since they do not use contraceptive methods, many pregnancies occur at two-year intervals. The average number of pregnancies for these women is seven. Breast-feeding continues for one and a half to two years, with lengthy lactation amenorrhea. Moreover, these women experience relatively early onset of menopause with the average at 42 years. Menopause occurs before the age of 40 in almost half of the women sampled, and none reported experiencing typical menopausal symptoms such as hot flashes. Furthermore, preliminary data indicates that Mayan women have a high calcium and low protein diet, maintain a relatively high level of physical activity, are obese, and do not smoke or drink alcohol. The selected culture would provide a unique and relatively isolated control for several risk factors which are assumed to be associated with postmenopausal osteoporosis, therefore, allowing us to identify the specific role of estrogen deprivation on skeletal health. The methods of data collection will include: a survey of prevalence of fractures in the population from clinical and hospital records, physical examination, blood analysis, bone density studies, and complete reproductive history of 100 rural and 100 urban Mayan women, as well as dietary calcium analysis in local foods. The findings will provide cross-sectional data on age- related skeletal and hormonal status of women in a culture which is unlike Western industrialized societies.

年龄和更年期相关骨骼的跨文化研究 没有变化，解决这个问题的详细研究将 为更年期、衰老和衰老的研究提供新的见解 骨质疏松症。 这项跨文化研究的目的是 是提供与年龄相关的模式的比较数据 不同文化背景下女性的骨骼和荷尔蒙状况 西方工业化社会。 所选文化 研究对象是墨西哥尤卡坦半岛东南部的玛雅农村妇女。 初步研究数据表明，与女性不同 在工业化的西方社会，大多数玛雅妇女早婚 他们的青少年。 由于不采取避孕措施，许多人 怀孕间隔两年发生一次。 平均数量 这些妇女的怀孕次数是七次。 母乳喂养持续 一年半至两年，有长时间哺乳闭经。 此外，这些女性的症状出现得相对较早。 更年期平均年龄为42岁。 更年期发生在 几乎一半的受访女性年龄在 40 岁左右，而且没有一个 据报告经历了典型的更年期症状，例如热 闪烁。 此外，初步数据表明，玛雅妇女 高钙低蛋白饮食，保持相对 高水平的体力活动、肥胖、不吸烟或 喝酒。 所选文化将提供独特且 对几个风险因素进行相对孤立的控制 被认为与绝经后骨质疏松症有关， 因此，使我们能够确定雌激素的具体作用 骨骼健康的剥夺。 数据收集的方法将包括： 从临床和临床数据来看，人群中骨折的患病率 医院记录、体检、血液分析、骨骼 密度研究，以及 100 个农村和地区的完整生殖史 100 名城市玛雅妇女，以及当地膳食钙分析 食物。 研究结果将提供年龄的横截面数据 文化中女性的相关骨骼和荷尔蒙状况 与西方工业化社会不同。