IV ANESTHETIC DISPOSITION IN THE AGED HEMODYNAMIC STATE

IV 老年血流动力学状态下的麻醉处置

• 批准号: 3115239
• 负责人: DONALD R STANSKI
• 金额: $ 19.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-01-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3115239
• 关键词: aging; anesthesia complication; anesthetics; binding proteins; brain metabolism; dosage; drug metabolism; electroencephalography; fentanyl; general anesthesia; human middle age (35-64); human old age (65+); human subject; mathematical model; morphine; narcotics; nitrous oxide; pharmacokinetics; postoperative state; preoperative state; sedative /hypnotic; surgery; young adult human (21-34)

A series of theoretical studies are proposed to develop and evaluate statistical approaches to resolving alternative hypotheses about the genetic and environmental determinants of aging and age-related diseases. Four approaches to the genetic analysis of age-related phenomena will be investigated: extension of time series models to incorporate genetic and environmental effects; analysis of the extent and cause of correlation between disease liability and age of onset; the statistical-genetic consequences of age-related degeneration of homeostatic control of gene regulation and sensitivity to the environment the incorporation of genetic and environmental heterogeneity into survival analysis models or age-dependent events. Computer programs will be developed to stimulate and analyze kinship data in each of the major areas of interest with the principal goal of deciding how far quantitative genetic studies of age related phenomena can elucidate the genetic and environmental processes underlying different aspects of the aging process. The resolving power of different strategies will be explored, and the effects of bias and errors of inference assessed. Appropriate methods will be applied to illustrative data from a large longitudinal study of cardiovascular risk in twins and their parents (N=330 families) and to a study of common age-dependent disease and disease-related risk factors in two large studies of twins and their relatives (N=5000 pairs and N=14000 twins plus 7000 relatives, approximately). By the end of the five year project the theoretical and computational tools available to genetic research into aging should be significantly enhanced.

提出了一系列理论研究来发展和 评估解决替代方案的统计方法 关于遗传和环境决定因素的假设 衰老和与年龄有关的疾病。 遗传的四种方法 将研究与年龄相关现象的分析：扩展 时间序列模型融合了遗传和环境 效果；分析范围和原因之间的相关性 疾病责任和发病年龄；统计基因 与年龄相关的稳态控制变性的后果 基因调节和对环境的敏感性 将遗传和环境异质性纳入 生存分析模型或与年龄有关的事件。 电脑 将开发程序来刺激和分析亲属数据 在每个关注的主要领域，其主要目标 确定与年龄相关的定量遗传研究 现象可以阐明遗传和环境过程 衰老过程的不同方面。 解决方案 将探索不同策略的力量，以及 评估了推理的偏差和误差。 适当的方法将 可以应用于大型纵向研究的说明性数据 双胞胎及其父母的心血管风险（n = 330个家庭）和 研究常见年龄依赖性疾病和疾病有关的研究 两次大型研究的风险因素及其亲戚 （n = 5000对，n = 14000个双胞胎加上7000个亲戚， 大约）。 到五年项目结束时 可用于遗传研究的理论和计算工具 衰老应该显着增强。