LIMBIC EPILEPSY: A NEUROBIOLOGIC APPROACH

边缘系统癫痫：神经生物学方法

• 批准号: 3099697
• 负责人: James O. McNamara
• 金额: $ 60.51万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099697
• 关键词: hippocampus; partial seizure

The objective of this proposal is to carry out a comprehensive research program focused on the study of basic mechanisms of limbic epilepsy. The proposal brings together investigators with expertise in anatomy, biochemistry, pharmacology, physiology, and clinical epilepsy. These skills will be focused on studies of both the kindling and kainic acid models of epilepsy in the rat. The proposal also includes characterization of some physiologic processes in hippocampal formation, namely dendritic inhibition and spike frequency adaptation, and will assess whether alterations of these fundamental processes are involved in epilepsy. Biochemical and morphologic studies will be performed on hippocampal formation surgically removed from humans with medically intractable complex partial epilepsy. The ultimate goal of all components of this proposal is to further our understanding of the basic mechanisms of epilepsy from study of model systems. This information should provide a rational basis for new pharmacologic approaches designed to more effectively treat or prevent human epilepsy.

本提案的目的是进行全面的研究 项目重点研究边缘系统癫痫的基本机制。 这 提案汇集了具有解剖学专业知识的研究人员， 生物化学、药理学、生理学和临床癫痫。 这些 技能将集中于火种和红藻氨酸的研究 大鼠癫痫模型。 该提案还包括特征描述 海马形成中的一些生理过程，即树突 抑制和尖峰频率适应，并将评估是否 这些基本过程的改变与癫痫有关。 将对海马进行生化和形态学研究 通过手术从具有医学上难治性复合物的人体中去除形成 部分性癫痫。 该提案所有组成部分的最终目标是 通过研究进一步了解癫痫的基本机制 的模型系统。 这些信息应该为新的开发提供合理的基础。 旨在更有效地治疗或预防的药物方法 人类癫痫症。