MECHANISMS OF POSTOPERATIVE PAIN

术后疼痛的机制

• 批准号: 2701841
• 负责人: TIMOTHY JOHN BRENNAN
• 金额: $ 10.76万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2701841
• 关键词: disease /disorder model; dorsal horn; electrophysiology; glutamate receptor; hyperalgesia; inhibitor /antagonist; laboratory rat; neural information processing; neurons; neurophysiology; neuropsychology; pathologic process; postoperative state; stimulus /response

DESCRIPTION: (Adapted from the applicant'S abstract) In this FIRST award proposal, the investigator proposes to use a rat model of postoperative pain that he has developed. He will test the hypothesis that incisional tissue injury results in a different form of spinal sensitization than that observed in other pain models. In parallel behavioral studies of mechanical hyper-algesia and single unit neurophysiology of spinal dorsal horn neurons, he will examine dorsal horn neuron threshold, receptive field size and background activity before and after incision; the effect of excitatory amino acid antagonists on the hyperalgesia; and the effect of the same antagonists on the sensitized spinal neurons.

描述：（改编自申请人的摘要）在此第一个奖项中 建议，研究者建议使用术后疼痛的大鼠模型 他已经开发了。 他将检验切口组织的假设 损伤会导致不同形式的脊柱敏化 在其他疼痛模型中观察到。 在机械的平行行为研究中 脊髓背角神经元的痛觉过敏和单一神经生理学， 他将检查背角神经元阈值、感受野大小和 切口前后的背景活动；兴奋作用 氨基酸拮抗剂对痛觉过敏的作用；和同样的效果 敏感脊髓神经元的拮抗剂。