NURSING THERAPY--ATTENTIONAL FATIQUE IN CANCER PATIENTS

护理治疗——癌症患者的注意力疲劳

• 批准号: 2445626
• 负责人: BERNADINE E. CIMPRICH
• 金额: $ 11.95万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2445626
• 关键词: attention; behavioral /social science research tag; breast neoplasms; clinical research; cognition; environment; fatigue; female; functional ability; human subject; human therapy evaluation; longitudinal human study; neoplasm /cancer therapy; nursing intervention; psychological aspect of cancer; psychological stressor; psychometrics; relaxation

DESCRIPTION: (Adapted from investigator's abstract) The proposed project evaluates the efficacy of a new intervention for attentional and functional restoration in women newly diagnosed with breast cancer. Preliminary data demonstrated that breast cancer patients manifested an attentional fatigue with reduced capacity to direct attention (CDA) during the three months following surgery and that such directed attention fatigue (DAF) could be ameliorated by a theoretically-based intervention involving regular exposure to natural restorative environment. Building on these findings, the project's specific aims are to determine whether: (a) a restorative environmental intervention can prevent or minimize losses in CDA over a longer period during and following breast cancer treatment; (b) any differences exist in the pattern and severity of DAF and the efficacy of the experimental intervention by type of breast cancer; (c) DAF produces an impairment in overall cognitive functioning; and (d) DAF is associated with poorer functional adjustment over time. Two hundred women, newly diagnosed with Stage I or II breast cancer, who will be treated either with breast conserving surgery plus radiation or mastectomy plus adjuvant chemotherapy, will be randomly assigned to receive usual care or an experimental intervention; a home-based program of 120 minutes per week of exposure to a natural restorative environment. Subjects will be assessed at five time points: before surgery (pre-intervention), about 2 weeks post-surgery, and at 3, 6, and 9 months post-surgery. The efficacy of the intervention over time on parameters of DAF, i. e., measures of the capacity to inhibit competing stimuli, will be evaluated using repeated measures ANOVA. Repeated measures ANOVA will also be used to compare the efficacy of the intervention within and between breast cancer treatment subgroups and any variations in pattern and severity of DAF. The ability to predict cognitive impairment in measures of short-term memory, higher level cognitive activities and cognitive control by DAF parameters will be tested using correlational and linear panel analyses. Finally, the associations between parameters of DAF and indicators of poorer functional adjustment, i.e. functional status, psychological distress, symptom distress, capacity to exert physical effort, and selected biological indices, will be examined. The ultimate aim of the research is to develop a theoretically based, low-cost intervention to restore attention and improve overall functioning in women treated for breast cancer.

描述：（改编自研究者的摘要）拟议的项目 评估新干预措施对注意力和功能的有效性 新诊断出乳腺癌的女性的康复。 初步数据 证明乳腺癌患者表现出注意力疲劳 三个月内直接注意力能力（CDA）下降 手术后，这种定向注意力疲劳（DAF）可能会 通过定期接触的基于理论的干预措施可以改善 到自然恢复环境。 基于这些发现， 该项目的具体目标是确定是否：(a) 恢复性 环境干预可以防止或最大限度地减少 CDA 的损失 乳腺癌治疗期间和治疗后的时间较长； (b) 任何 DAF 的模式和严重程度以及治疗效果存在差异 按乳腺癌类型进行实验干预； (c) DAF 产生 整体认知功能受损； (d) DAF 与 随着时间的推移，功能调整会变差。 200 名新诊断女性 患有 I 期或 II 期乳腺癌，将接受乳腺癌治疗 保留手术加放疗或乳房切除术加辅助化疗， 将被随机分配接受常规护理或实验性护理 干涉;每周 120 分钟的家庭计划 自然恢复环境。 受试者将分五次进行评估 要点：手术前（干预前）、手术后约2周、以及 术后 3、6 和 9 个月。 干预效果超过 DAF 参数的时间，i。 e. 抑制能力的测量 竞争刺激，将使用重复测量方差分析进行评估。 重复测量方差分析也将用于比较 乳腺癌治疗亚组内部和之间的干预以及任何 DAF 的模式和严重程度存在差异。 预测认知能力 短期记忆、高级认知能力受损 DAF 参数的活动和认知控制将使用以下方法进行测试 相关性和线性面板分析。 最后，之间的关联 DAF 的参数和功能调整较差的指标，即 功能状态、心理困扰、症状困扰、能力 进行体力活动和选定的生物指标进行检查。 研究的最终目的是开发一种基于理论的、 恢复注意力和改善整体功能的低成本干预 在接受乳腺癌治疗的女性中。